Wuhan Textile University Yanbo Liu: Characterizationon Modification and Biocompatibility of PCL Scaffold Prepared with Near-field Direct-writing Melt Electrospinning 2021-06-26
Polycaprolactone(PCL) due to its good biocompatibility and biodegradability, is widely used in fracture fixation materials, surgical sutures, medical dressings, controlled drug release materials and tissue engineering scaffold materials. The research group of Professor Liu Yanbo from the School of Textile Science and Engineering of Wuhan Textile University explored the best process parameters for preparing PCL scaffoldsusing near-field direct-writingmelt electrospinning technology through orthogonal experiments. Based on the optimized process parameters, PCL scaffolds with different thicknesses, gaps and structures were prepared, and the corresponding hydrophilicity was characterized. The PCL scaffold is modified with chitosan (CS) and hyaluronic acid (HA) to improve biocompatibility and hydrophilicity. Fourier transform infrared spectroscopy (FTIR) analysis and antibacterial experiment results show that the adhesion of chitosan and hyaluronic acid on the surface of the PCL scaffoldhas