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Electrospun nanofiber dressings have become a research hotspot due to their advantages such as easy manufacturing, low cost and structural similarity with the extracellular matrix. Coaxial electrospun nanofibers have considerable advantages in drug delivery, fiber structure transformation and enhanced interaction with the host. Recently, Professor Tang Shijie and others from the Second Affiliated Hospital of Shantou University Medical College published a review summarizing the latest application progress of coaxial electrospun nanofibers in wound dressings. The relevant content was published in the journal Materials Today Bio under the title "Recent advances in coaxial electrospun nanofibers for wound healing".
The main point of this paper
1.A comprehensive overview of wound healing and its influencing factors is given.
2.The production principle of coaxial electrospinning and its application in wound dressings are also outlined.
3.Depending on the factors affecting wound healing, coaxial electrospinning nanofiber dressings have different application methods.
4. In addition, the limitations of current coaxial electrospinning finishing technology and future development directions are discussed.
1.Mimicking the Extracellular Matrix (ECM): The nanofibers closely resemble the structure of the ECM, which is essential for supporting cellular activities required for effective wound healing, such as cell adhesion, migration, and proliferation.
2.Enhanced Surface Area: The nanometer size of the electrospun fibers significantly increases the surface area to volume ratio, which facilitates better cell adhesion and interaction, promoting faster healing.
3. Morphological Control: Electrospinning technology allows for precise control of the morphology of the nanofibers, including their alignment and diameter. Highly aligned fibers can guide cell migration and enhance re-epithelialization, which is essential for wound closure.
4. Interconnected Porous Structure: The interconnected porous nature of the electrospun nanofiber dressing supports important cellular activities, including angiogenesis (formation of new blood vessels), gas exchange, and absorption of wound exudate. This helps maintain a moist environment conducive to healing.
5. Optimized Pore Size: The ideal pore size range is typically between tens to hundreds of microns, which is consistent with the pore size of the electrospun nanofiber dressing. This helps effectively manage the exchange of exudate and nutrients.
6. Controlled Drug Release: Coaxial electrospinning technology allows for the embedding of therapeutic agents within the fibers, enabling controlled and sustained release of drugs at the wound site, which can enhance healing and reduce infection.
1. Advanced wound dressings: The development of coaxial electrospun nanofibers can enable the development of more effective wound dressings that not only promote healing but also provide controlled drug release, reduce the risk of infection, and improve patient outcomes.
2. Personalized medicine: The ability to tailor the properties of nanofibers (such as fiber diameter, porosity, and drug loading) allows wound dressings to be tailored to the specific needs of individual patients, thereby enhancing the effectiveness of treatment.
3. Integration with biosensors: Future applications may include integrating biosensors into nanofiber dressings to enable real-time monitoring of the wound environment.
4. Regenerative medicine: The structural similarity of electrospun nanofibers to the extracellular matrix makes them promising candidates in tissue engineering and regenerative medicine, potentially helping to repair and regenerate a variety of tissues beyond the skin.
5. Drug delivery systems: Coaxial electrospinning technology can be used to develop advanced drug delivery systems that provide sustained and localized release of therapeutic agents.
6. Research and Development: This study opens new avenues for further optimizing electrospinning technology and exploring new materials, including biocompatible and biodegradable polymers, which may enhance the safety and effectiveness of medical applications.
7. Cost-effectiveness: The low-cost and high-efficiency nature of electrospinning technology may lead to the widespread availability of advanced wound care products, making them accessible to a larger population and potentially reducing the medical costs associated with wound management.
