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Recently, Prof. Min Zhao of Queen's University Belfast, UK, presented electrospinning technology for biological drug delivery, including its current status and future trends. This work aims to provide valuable insights into the evolving field of electrospinning biopharmaceutical drug delivery systems. The work was published in the journal “Electrospinning technologies for the delivery of Biopharmaceuticals: Current status and future trends”. International Journal of Pharmaceutics.
1.This paper reviews the application of electrospinning technology in biopharmaceutical delivery, focusing on different types of biopharmaceuticals, such as proteins, nucleic acids and hormonal drugs, and their complexation with polymeric nanofibers.
2.Various methods of incorporating biopharmaceuticals into Electrospun Nanofbers, such as surface adsorption, blending, emulsion, coaxial and high throughput electrostatic spinning, are elaborated.
3.In addition, the current research status and future trends of electrospinning technology in the field of biological drug delivery are discussed.
4.Analytical techniques for characterizing Electrospun Nanofbers are outlined and legal and regulatory requirements for their production are discussed.
1. Surface adsorption:
A relatively simple process, the loading and release rate of the drug usually depends on the nature of the fiber surface and the adsorption method, but the composition ratio and stability are the key issues to be solved.
2.Drug encapsulation:
Involves dissolving the drug into the electrospinning solution prior to electrospinning, thereby dispersing the drug directly in the fiber. Preparation processes and methods determine the structure, encapsulation efficiency and drug release behavior in such fibers.
1. Wound dressing:
Electrospun nanofibers can be used to prepare wound dressing with good biocompatibility, degradability and high surface area, which can promote wound healing.
2. Ocular delivery:
Electrospun nanofibers can be used to prepare ocular delivery systems, which can improve the residence time of drugs on the ocular surface, enhance the permeability of drugs, and reduce drug side effects.
3. Transdermal delivery:
Electrospun nanofibers can be used to prepare transdermal delivery system, which can be used to give drugs directly through the skin, avoiding gastrointestinal absorption and improving drug bioavailability.
4. Vaginal delivery:
Electrospun nanofibers can be used to prepare vaginal delivery system, which can deliver the drug directly to the vagina, improve the local concentration of the drug and enhance the therapeutic effect.
5. Oral targeting:
Electrospun nanofibers can be used to prepare oral targeting delivery system, which can deliver drugs to specific parts of the intestines, improve drug absorption rate and reduce drug side effects.
1. Drug stability:
The organic solvents used in the electrospinning process may lead to drug degradation, so new electrospinning methods need to be developed to avoid the use of organic solvents.
2. Scale production:
Electrospinning technology is currently difficult to achieve large-scale production, the need to develop new electrospinning equipment and processes to improve production efficiency.
3. Regulatory requirements:
The application of electrospinning technology in biopharmaceutical delivery systems needs to meet strict regulatory requirements, including safety, efficacy and quality control.
The application of electrospinning technology in biopharmaceutical delivery systems is promising, with the continuous progress of technology, electrospinning technology is expected to play an increasingly important role in the field of biopharmaceuticals.
Originallink: https://doi.org/10.1016/j.ijpharm.2023.123641
