Copyright © 2022 Foshan MBRT Nanofiberlabs Technology Co., Ltd All rights reserved.Site Map
Recently, Prof. Weifeng Zhao, from the team of Prof. Changsheng Zhao at Sichuan University, has prepared a PVA- fp -CMC Nanofiber Membrane by interweaving PVA/CMC and PVA/Fe-PMA fibers through a bi-directional Electrospimning Setup, which has excellent Exudate Absorption and Super Bactericidal Capacity for Bacteria-induced Gelatinizable Nanofiber Membranes (EGCMC). The related research results are presented as “Exudate-Induced Gelatinizable Nanofiber Membrane with High Exudate Absorption and Super Bactericidal Capacity for Bacteria- Infected Wound Management” was published in the journal Advanced Healthcare Materials.
1. A gelatable, near-infrared (NIR)-responsive Nanofiber Membrane composed of polyvinyl alcohol (PVA), carboxymethyl chitosan (CMC), and iron-doped phosphomolybdic acid (Fe-PMA), which exhibits excellent exudate absorption and effective bactericidal efficacy, has been developed and is referred to as a PVA-FP -CMC membrane.
2. The unique exudate-induced gelation process gives the membrane a high exudate absorption and retention capacity, and the hydrogel formed also traps bacteria that multiply in the exudate.
3. It was also found for the first time that the photothermal conversion ability and photocatalytic activity of Fe-PMA were higher than that of PMA. therefore, the presence of Fe-PMA provided the membrane with the therapeutic effect of photothermal and photodynamic killing of bacteria.
4. The liquid absorption of PVA-FP-CMC membrane was 520.7%, the photothermal conversion efficiency was 41.9%, the generation of hydroxyl radical (-OH) and singlet oxygen (1O2) was high, and the killing rates of Staphylococcus aureus and Escherichia coli were 100% and 99.6%, respectively.
1. PVA-FP-CMC nanofibrous membranes were prepared by mixing polyvinyl alcohol (PVA)/carboxymethyl chitosan (CMC) hybrid spinning solution (PVA/CMC) and PVA/Fe-PMA spinning solution (PVA/Fe-PMA) through a bidirectional electrospinnig machine.
2. The hydrophilic polymers PVA and CMC provided the ability to absorb wound exudate, and the absorbed exudate induced the transformation of the PVA-FP-CMC nanofiber membrane into a hydrogel membrane with a dual-network cross-linking structure.
3. When the PVA-FP-CMC membrane was applied to bacterial infected wounds, the fibers rapidly absorbed the excess wound exudate, and the bacteria were killed by the uniform PTT effect generated by 808 nm near infrared light irradiation.
1. It can be converted into a hydrogel film after absorbing wound exudate. Exudate-induced gelation can effectively absorb and retain exudate.
2. It forms a dual network cross-linking structure in the hydrogel. PVA and CMC form the first network through hydrogen bonding and entanglement, and Fe-PMA forms the second network through ligand bonding with CMC. This double cross-linking improves mechanical strength and liquid retention.
3. It contains Fe-PMA, which generates heat under near-infrared irradiation while generating reactive oxygen species (ROS) such as hydroxyl radicals and singlet oxygen, giving it photothermal and photodynamic sterilizing properties.
4. The uniform distribution of Fe-PMA in the fiber produces uniform photothermal conversion and photodynamic effects under NIR irradiation instead of localized overheating.
5. It exhibits a high osmotic absorption rate of 520.7% and a photothermal conversion efficiency of 41.9%. It also showed strong antibacterial effects against Staphylococcus aureus and Escherichia coli.
6. It has been shown to promote wound healing in mouse model experiments and is non-toxic.
In conclusion, its unique exudate-induced gelation and dual-network structure, as well as its photothermal and photodynamic properties endow it with highly efficient exudate management capabilities and bactericidal functions for wound treatment.
Originallink: https://doi.org/10.1002/adhm.202303293
