Electrospinner: Electrospun nanofiber-derived functional scaffolds for cancer therapy

Research background

Challenges in cancer treatment: Cancer is a deadly disease. Traditional treatment methods include surgery, chemotherapy, and radiotherapy, which have problems such as nonspecific distribution and low tumor target levels.

Electrospinning technology: The technology of using electrostatic force to spray polymer solutions into nanofibers has the characteristics of large surface area, high load capacity, and easy modification.

Characteristics of nanofibers: Electrospun nanofibers have a microstructure similar to the extracellular matrix (ECM), which promotes cell adhesion and proliferation and is beneficial to tissue regeneration.

Abstract

Cancer treatment platform: Electrospun nanofiber-derived scaffolds are a promising cancer treatment platform that allows the delivery of therapeutic ingredients at the target site and reduces adverse effects on normal tissues.

Review content: The latest research on electrospun nanofibers and their derived composite scaffolds in the field of cancer treatment, including chemotherapy, photodynamic therapy, thermal therapy, gene therapy, etc. is reviewed.

Analysis

Technical advantages: Electrospinning technology can produce nanofibers with high porosity and large surface area, which are suitable as drug carriers to improve therapeutic effects.

Therapeutic efficiency and multifunctionality: Electrospun nanofiber-derived scaffolds can achieve controlled release of drugs and have multifunctional properties such as anti-adhesion and hemostasis.

Challenges in clinical translation: Although electrospun nanofiber-derived scaffolds have shown potential in cancer treatment, they still face challenges in clinical translation, such as effective drug penetration and drug resistance issues.

Future directions: Optimize synergistic effects and develop innovative scaffold-based strategies to achieve precise and effective cancer treatment while reducing systemic toxic side effects.

Conclusion

Unique properties of nanofibers: Electrospun nanofibers have a large surface area, a variety of matrix materials, the ability to load and deliver a variety of drugs, and high porosity.

Potential for cancer treatment: These properties make electrospun nanofibers have great potential in a variety of cancer treatments, including chemotherapy, PDT, hyperthermia, gene therapy, etc.

Combination therapy and multifunctional therapy: Electrospun nanofiber-derived scaffolds can serve as a multimodal combination therapy platform, allowing the co-delivery of multiple therapeutic drugs.

New strategies and optimization: Researchers are committed to optimizing drug loading and release properties and developing new strategies to control drug release to achieve sustained and localized delivery of therapeutic drugs to tumor sites.