Electrospinner: Flexible Copper-Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti-inflammatory Effects

Research background

Recently, Professor Mo Xiumei and a team of researchers led by Zhou Xingping from Donghua University published research results on the development of nanofibers with antibacterial and anti-inflammatory effects in the journal Advanced Fiber Materials, titled "Flexible Copper Supported Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti inflammatory Effects".

Methods

Researchers developed copper-doped flexible silicate nanofibers (SiO2@Cu NFs) that have multifunctional antibacterial and anti-inflammatory properties, exhibit good biocompatibility, and promote cell growth, angiogenesis, and inflammation regulation.

Research highlights

SiO2@Cu NFs exhibit excellent antioxidant capacity and promote wound healing. Studies have shown that copper nanoparticles can promote the activity of catalase (CAT), enhance the detoxification effect of hydrogen peroxide, and promote antioxidant activity.

SiO2@Cu NFs have significant free radical scavenging rate and exhibit strong antioxidant effects.

Copper ion release can induce anti-inflammatory effects, help resolve inflammation and promote wound healing.

Copper-doped silicate nanofibers exhibit significant antibacterial properties by releasing copper ions, which can effectively promote the repair of infected conjunctival tissue.

These fibers can significantly inhibit the growth of bacteria such as Staphylococcus aureus and reduce the formation of bacterial colonies in vitro and in vivo.

The released copper ions also have the ability to induce anti-inflammatory effects, which may help to reduce inflammatory responses at the wound site.

These fibers exhibit good biocompatibility and can promote cell growth, angiogenesis, and inflammation regulation, thereby supporting the tissue repair process.

Conclusion

The copper-doped flexible silicate nanofibers designed by the research team have good physicochemical properties and biocompatibility.

It can induce angiogenesis and polarization of macrophages toward an anti-inflammatory phenotype and has antibacterial properties.

The results have the potential to replace eye patch dressings, promote conjunctival regeneration, and have a positive impact on other ophthalmic wounds.

Electrospinning Nanofibers Article Source:

https://link.springer.com/article/10.1007/s42765-023-00358-5