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Potential of silk fibroin (SF) microspheres: SF microspheres have broad application prospects in the fields of microcarriers, drug delivery, tumor embolic agents and microscaffolds. Non-chemical preparation methods are essential to maintain the bioactivity and biocompatibility of SF.
Electrostatic spraying and cryo-induced assembly: The SF solution was sprayed into liquid nitrogen to form frozen microspheres, and then annealed to prepare silk I crystal SF microspheres. This method avoids the use of organic solvents and cross-linking agents and is a green preparation method.
Stability and degradability: SF microspheres can maintain their morphology in water for up to 30 days, and the degradation rate in PBS after 14 days is 77%, showing high stability and a suitable degradation rate.
Surface structure: The surface of SF microspheres has interconnected pores, which is conducive to cell adhesion, proliferation and drug release.
Crystal structure: The SF microspheres after cryo-annealing have a silk I crystal structure and have better water stability than the untreated amorphous SF microspheres.
Cell Culture: SF microspheres supported the growth and expansion of mammalian cells (HUVECs) and showed good biocompatibility.
Drug Delivery: SF microspheres can effectively encapsulate and release small molecule drugs (such as doxorubicin DOX), achieving sustained release within 10 days.
Electrospinning Technology: Although electrospinning technology was not used in this study, the preparation and application of SF microspheres have similarities with electrospinning technology, especially in the preparation of biomaterials with specific structures and functions. Electrospinning technology can produce nanofibers with high specific surface area and high porosity, which are also important for drug delivery and tissue engineering.
Biomaterial Design: Both the preparation method of SF microspheres and electrospinning technology emphasize the importance of designing and preparing high-performance biomaterials without the use of harmful chemicals.
Green Preparation Method: This study provides a non-chemically reactive method to prepare non-water-soluble SF microspheres with high stability and biocompatibility, which is suitable for the biomedical field.
Multifunctional applications: SF microspheres show potential in drug delivery and cell culture, supporting cell growth and achieving sustained drug release.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1016/j.ijbiomac.2024.134927
