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Oral fast-dissolving film is a new drug delivery system with the characteristics of rapid dissolution and absorption, suitable for drugs that need to take effect quickly. There are various preparation methods, including solution casting, hot melt extrusion, electrospinning technology and 3D printing technology. Each method has its advantages and disadvantages and is suitable for different types of drugs and needs.
Solution casting: simple and convenient, but there may be problems with solvent residue and film stability.
Hot melt extrusion: solvent-free, suitable for improving drug solubility, but not suitable for heat-sensitive drugs.
Electrospinning technology: improves the solubility of poorly soluble drugs and is suitable for fast-dissolving films.
3D printing technology: good stability, accurate drug loading, suitable for personalized drug delivery, but not suitable for large-scale production.
In terms of quality evaluation, multiple indicators such as sensory evaluation, mechanical properties, content uniformity, phase analysis, in vitro disintegration time and in vitro dissolution need to be considered.
Select a suitable preparation process according to the thermal stability and solubility of the drug.
For heat-sensitive drugs, hot melt extrusion should be avoided.
For poorly soluble drugs, electrospinning technology can improve their solubility.
Sensory evaluation directly affects patient acceptance and medication compliance.
Mechanical property evaluation ensures the physical stability and ease of use of the film.
Content uniformity and phase analysis ensure the efficacy and safety of the drug.
In vitro disintegration time and dissolution tests simulate the release and absorption process of the drug in the body.
The development of 3D printing and electrospinning technology has provided new possibilities for the preparation of oral fast-dissolving films, especially in personalized drug delivery and improving the bioavailability of poorly soluble drugs.
The application of these new technologies requires further research and optimization to achieve large-scale production and cost-effectiveness.
With the increasing demand for personalized medicine and precision drug delivery, 3D printing technology may play a greater role in the preparation of oral fast-dissolving films in the future.
For improving the solubility and bioavailability of poorly soluble drugs, electrospinning technology and other new technologies will continue to be studied and developed.
Electrospinning Nanofibers Article Source:
https://kns.cnki.net/kcms2/article/abstract?v=2iaLu-A-XVlC40Qa9U9Exv1fu2MMirCMxhpRLqSC5YkhZ9ng7zFvNvdk4FETjFdMnmbqF2wpkBKipUNAUbrx6z_a_dKsfHkegpov2z1UXFn76M8vFY_l6-TEfdJy9U5DEsQ0TLwWBiHNBtunBoPD10wiMl8ogPHWbKicBLZilyg=&uniplatform=NZKPT
