Copyright © 2022 Foshan MBRT Nanofiberlabs Technology Co., Ltd All rights reserved.Site Map
Electrospinning is an important technology for manufacturing micro/nanofiber platforms, which can be used for biomedical scaffolds for tissue engineering repair and regeneration. In recent years, researchers have continuously broadened the equipment design and material development of electrospinning nanofiber platforms (ENPs), from single needle to multi-needle, for the manufacture of 3D ENPs, diversifying their application range, including drug/cell/growth factor release, antibacterial and anti-inflammatory, hemostasis, wound healing, tissue repair and regeneration.
Recently, Professor Li Hongbin of Qiqihar University and others published a review summarizing the development of electrospinning technology, the development of multifunctional scaffolds and their applications in various tissue types, including bone, cartilage and nerves. The relevant research content was published in the journal Advanced Functional Materials (IF 18.5) with the title "Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application".
1. This review summarizes the material design, structural construction, and different requirements of ENPs scaffolds made of bioactive polymers prepared by electrospinning technology in different tissue engineering regeneration.
2. This review deeply explores the recent progress of ENPs in promoting tissue repair, emphasizing their effectiveness and versatility in various tissue types such as bone, cartilage, tendon, cardiac tissue, and nerve.
3. The discussion comprehensively addresses the ongoing challenges in material selection, biodegradation mechanisms, bioactivation strategies, and manufacturing technologies specific to tissue repair applications.
4. In addition, this review outlines potential future research avenues aimed at enhancing ENPs-based approaches in tissue engineering.
1. Development of multifunctional nanofiber scaffolds: Researchers are exploring new materials and structural designs to create electrospun nanofiber scaffolds with multiple functions. These scaffolds can be used to release drugs, cells, and growth factors, have antibacterial and anti-inflammatory properties, and can promote hemostasis, wound healing, and tissue repair and regeneration.
2. Coaxial and triaxial electrospinning techniques: The application of these techniques can produce nanofibers with core-shell structures, which can effectively combine multiple bioactive materials, help control drug release, and improve the functionality of scaffolds.
3. Multi-material electrospinning: The development of electrospinning equipment that can handle multiple materials can produce a variety of nanofiber geometries. This flexibility can incorporate growth factors, antimicrobial agents, and living cells into electrospun nanofibers, thereby accelerating wound repair and regeneration.
4. Process optimization and control: In-depth research on various factors in the electrospinning process (such as polymer solution properties, flow rate, voltage, temperature, and humidity) has improved the morphology and quality of nanofibers, and improved their consistency and reliability in biomedical applications.
5. Green electrospinning technology: With the increasing emphasis on environmental protection, researchers have begun to explore green electrospinning methods that reduce the use of harmful solvents to improve the biocompatibility and sustainability of materials.
1. Simulation of the extracellular matrix (ECM): Electrospun nanofibers are able to simulate the natural extracellular matrix, providing a supportive environment for cell attachment, proliferation and differentiation, thereby helping to promote the natural healing process of tissues.
2. High surface area to volume ratio: The high surface area of electrospun nanofibers enhances cell interactions and nutrient exchange, creating a microenvironment that is conducive to tissue repair.
3. Controlled drug release: Electrospun nanofibers can be designed to contain bioactive agents, thereby achieving controlled and sustained release of drugs, growth factors or other therapeutic agents. This ability helps manage inflammation and infection at the wound site, further supporting the healing process.
4. Property customization: The electrospinning process allows the use of a variety of materials, including synthetic and natural polymers, which can be customized according to specific mechanical, chemical and biological properties.
5.Antibacterial and hemostatic properties: Electrospun nanofibers can be designed to have antibacterial properties, thereby reducing the risk of infection. In addition, they can also promote hemostasis.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1002/adfm.202406950
