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Electrospinning technology is widely used in regenerative medicine because of its advantages such as its ability to simulate the natural structure of the extracellular matrix. Through electrospinning equipment, researchers were able to create scaffolds with specific properties to promote the regeneration and integration of tendon and bone tissue. This shows that the application of electrospinning technology in tendon-bone interface tissue engineering has important value.
The silk collagen scaffold developed by Professor Ouyang Hongwei's team has a "sandwich" structure, with knitted silk incorporated between two layers of collagen sponges. Although electrospinning equipment was not directly used in this study, electrospinning technology can be used to prepare nanofibers with specific orientations and structures, which can be used to enhance the mechanical properties and biocompatibility of scaffolds, thereby promoting ligament-bone healing.
Electrospinning technology shows great application prospects in the preparation of high-performance tissue engineering scaffolds, especially in tendon-bone interface tissue regeneration. Nanofiber scaffolds prepared by electrospinning equipment can provide better cell directional growth and mechanical properties, which are essential for ACL reconstruction and ligament-bone healing.
Electrospinning machines will be optimized and innovated in terms of equipment structure, control system and process parameters to improve production efficiency, reduce energy consumption and improve product quality. These technological innovations will further promote the application of electrospinning technology in tissue engineering, including ACL regeneration and ligament-bone healing.
Control the parameters of the spinning solution: Parameters such as viscosity, surface tension and conductivity of the spinning solution have a direct impact on the fiber diameter. By adjusting the concentration and composition of the spinning solution, the diameter of the fiber can be changed. For example, increasing the viscosity of the spinning solution can increase the diameter of the fiber, while increasing the conductivity may lead to a decrease in the fiber diameter.
Adjust the electric field strength: The applied electric field strength is a key factor affecting the fiber diameter. The higher the electric field strength, the more charge accumulates on the spinning solution, and the thinner the jet formed under the action of the electric field force.
Optimize nozzle design: The design and size of the nozzle will also affect the diameter of the fiber. The inner diameter size, shape and distance of the nozzle from the receiver will affect the formation and diameter of the fiber.
The research of Professor Ouyang Hongwei's team showed that silk collagen scaffolds have clinical application value in ACL regeneration. Combined with electrospinning technology, the structure and performance of the scaffold can be further improved, and cell growth and tissue healing can be promoted. The application of electrospinning equipment provides new solutions for tissue engineering and regenerative medicine, especially in the field of ligament-bone healing. With further development of technology, electrospinning technology is expected to play a greater role in clinical practice.
Electrospinning Nanofibers Article Source:
http://dx.doi.org/10.1016/j.actbio.2017.02.027
