Electrospinning Device: Acellular chitosan/silk fibroin/bioactive glass scaffolds with radial pores for in situ induced regeneration of critical-sized bone defects

Background

Electrospinning technology is widely used in regenerative medicine because of its advantages such as being able to simulate the natural structure of the extracellular matrix. Through electrospinning technology, natural materials or polyester materials with good biocompatibility and biodegradability can be prepared into micron or nanoscale continuous fibers, which have been widely used in the field of tissue engineering.

Preparation of bioactive scaffolds by electrospinning equipment

Electrospinning equipment can prepare nanofiber scaffolds with specific structures. These scaffolds can be loaded with bioactive molecules or incorporated with functional components to provide rich biochemical substances and biophysical clues, effectively regulate cell behavior, and restore the function of damaged tissues.

Preparation of CS/SF/BG composite scaffolds by electrospinning

The CS/SF/BG composite scaffold mentioned in this study has a unique radial pore structure, and its structure and performance can be further optimized by electrospinning technology. Electrospinning technology can be used to prepare nanofibers with specific orientations and structures, which can enhance the mechanical properties and biocompatibility of scaffolds, thereby promoting bone regeneration.

Electrospinning technology and bone tissue engineering

The progress of the application of electrospinning technology in bone tissue engineering shows that the scaffolds prepared by electrospinning equipment can induce skeletal muscle cell orientation and differentiation. In addition, electrospinning technology can also be used to manufacture micro-nano composite scaffolds with dual functions of antibacterial and osteogenic, which is of great significance for bone defect repair.

Innovative application of electrospinning equipment

The synergistic effect of electrospinning technology and 3D printing technology in the manufacture of bone scaffolds provides new possibilities for the manufacture of personalized and precise bone tissue engineering scaffolds. This combination can improve the bioactivity of the scaffold and promote bone tissue regeneration.

Conclusion

Electrospinning technology has great application potential in tissue engineering, especially in bone tissue engineering. The CS/SF/BG composite scaffold prepared by electrospinning equipment combines the advantages of chitosan, silk fibroin and bioactive glass, showing good physical and chemical properties and biocompatibility, and provides a promising therapeutic strategy for bone defect repair. The development and application of electrospinning technology will further promote the progress of tissue engineering and regenerative medicine.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.carbpol.2024.121945