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Drug delivery is the technology and method of delivering drugs to specific parts of the body in an appropriate manner to achieve therapeutic effects. Its core lies in the rational design of the drug carrier and release system to ensure that the effective concentration of the drug can be maintained at the target site for a long period of time, while at the same time reducing side effects and drug wastage.
Electrospun Nanofbers can significantly enhance drug delivery efficiency and therapeutic effects due to their ultrafine structure and excellent material properties. Therefore, nanofibres have a broad application prospect in the field of drug delivery.
the material should be compatible with human tissues and cells and not cause immune reaction or inflammation.
the material should be able to gradually degrade into harmless small molecules in the body and be metabolised or excreted. The degradation rate should be matched with the drug release rate to achieve precise control of release.
can load different types of drugs (such as small molecule drugs, biological drugs or proteins).
the structure of the material should support the slow release or rapid release of drugs, to achieve a stable release of drugs within a specific time.
the material should be physically and chemically stable, and will not be denatured or degraded in storage and in vivo environment. The material can be processed by electrospinning machine.
Nanofibres for drug delivery are prepared in a variety of technologies, including Industrial Electrospinning machine production Line, Needle-Based Industrial Electrospinning machine, Scale-up Electrospinning machine etc. The preparation method of different electrospinning equipments affects the structure of the fibres, the drug loading mode and the release characteristics.
1, The high specific surface area and porous structure of Electrospun Nanofberss help the efficient loading of drugs and enhance the drug encapsulation capacity.Nanofiber filter media for topical therapy or implantable carriers.
2. Drugs can be embedded in the fibre matrix to achieve slow or sustained release and reduce the frequency of drug delivery. By adjusting the spinning conditions and material selection, a bilayer or multilayer structure can be achieved to support multi-stage release.
3. Electrospun Nanofbers can be made into Nanofiber Membrane, scaffolds, patches or implants for local drug delivery (e.g. wound dressings, ophthalmic drug delivery). By functionalising the fibre surface, targeting can be enhanced, e.g. precise delivery of drugs to tumours or specific organs.
4.By controlling the parameters of the electrospnning device, different morphologies of fibres can be prepared, such as hollow fibres, core-shell structures, etc., to meet different drug delivery needs.
Electrospun Nanofbers can be used as scaffold materials for cell culture and tissue regeneration, promoting repair and regeneration of damaged tissues.
Electrospun Nanofbers can be used as carriers for drugs to achieve controlled release and targeted delivery of drugs to improve the efficacy of drugs and reduce side effects.
Electrospun Nanofbers can be prepared into dressings with good air permeability and adsorption properties for wound healing and protection.
Electrospun Nanofbers can be used to prepare biosensors and diagnostic platforms for biomarker detection and disease diagnosis.
Electrospun Nanofbers can be used to prepare medical devices, such as artificial blood vessels, artificial organ scaffolds and so on.
These electrospimnig machine applications fully demonstrate the potential of green electrospun nanofibres in the biomedical field, providing new material options and solutions for healthcare.
Original link: https://kns.cnki.net/kcms2/article/abstract?v=D99zBTMMfgzsW4qYe0n0rK50FkebkO2MhRjTAw1353JEc-Rhb3Db9_aiSlUOIc-7ddqhjsKQkBu2Y0kf2CXg2Xe4Bv_COM-GtHWAfgO2T1dQL312t1OcChpDjRldb8p-Xk_zXkG77_nWdWWXxuZ9_5VJsTLq7pMEySwDsX-Fpkw=&uniplatform=NZKPT
