Electrospining Machine: Electrospun Nanofbers scaffolds in vascular grafts

Literature introduction

Defects in blood vessels caused by trauma or vascular disease can severely impair normal blood circulation and lead to serious health complications. Vascular grafting has become a popular method of revascularisation with favourable outcomes. Conventional stents often suffer from poor biocompatibility, thrombosis, and restenosis. In contrast, Electrospun Nanofbers scaffolds produced by Electrospining  Machine possess high specific surface area, good biocompatibility and adjustable mechanical properties, making them ideal scaffoldmaterials.

What are the advantages of Electrospun Nanofbers scaffolds?

1.High specific surface area: 

Electrospun Nanofbers have a large specific surface area, which can provide a better environment for cell attachment and growth.

2.Good biocompatibility: 

By choosing suitable polymer materials, Electrospun Nanofbers scaffolds can achieve good biocompatibility and reduce immune reactions.

3.Adjustable porosity: 

electrospinning equipmen can precisely control the diameter and porosity of the fibres to optimize cell penetration and nutrient delivery.

4.adjustable mechanical properties:

by adjusting the fibre material and structure, it can achieve mechanical properties that match biological tissues and provide adequate support.

5.Promote angiogenesis:

Electrospun Nanofbers scaffolds can promote endothelial cell migration and proliferation, support angiogenesis and promote healing.

6.Drug release function:

drugs can be embedded in the scaffold to achieve slow release, helping to reduce postoperative complications or promote tissue regeneration.

 A case for Electrospun Nanofbers scaffolds for vascular grafts

CASE INTRODUCTION:

The researchers firstly synthesised the macromolecular hydrogen sulphide donor KAT using keratin with good biocompatibility, which improved the stability of H2S release and prolonged the release cycle. Further, the stent fabricated by the investigators with electrospimnig umit still has clear blood flow signals without blockage after 6 months of implantation in vivo and has long-term patency rate

CASE PRESENTATION: 

This study fabricated layered vascular grafts by electrospinning machine, braiding and thermally induced phase separation (EBT) processes, which can mimic the structure of natural blood vessels. The internal electrospun structure facilitates the adhesion of endothelial cells, thus accelerating endothelialisation. The intermediate PLGA fabric exhibits excellent mechanical properties that allow it to maintain its shape and prevent graft expansion during long-term transplantation. The external macroporous structure facilitates cell growth and infiltration.EBT vascular grafts (EBTVGs) have mechanical properties to match, reliable cytocompatibility and the strongest endothelialisation in situ!

Original link: https://doi.org/10.1002/adhm.202302676