Electrospining Machine: Electrospun Nanofbers Scaffold Promotes Diabetic Wound Healing

Research background

Electrospun Nanofbers scaffolds have structural similarities to the extracellular matrix (ECM), which promotes fibroblast adhesion, growth, and migration, thereby facilitating the formation of new skin tissue at the wound site.The composition and size of Electrospun Nanofbers scaffolds can be easily adjusted to achieve controlled drug release through fibrous structural modifications. The porous nature of these scaffolds facilitates gas exchange and wound exudate absorption. In addition, the fiber surface can be easily modified to confer specific functionality, making Electrospun Nanofbers scaffolds very promising for the treatment of diabetic wounds.

The main points of this paper

1.The healing process of normal wounds and the pathological mechanisms of diabetic wounds, including complications such as diabetic foot ulcers, are briefly summarized.

2.The advantages of Electrospun Nanofbers scaffolds in the treatment of diabetic wounds are discussed.

3.Summarized the results of various studies using different types of Electrospun Nanofbers scaffolds for the treatment of diabetic wounds, and reviewed the methods of drug loading on Electrospun Nanofbers scaffolds.

How do Electrospun Nanofbers scaffolds promote diabetic wound healing?

1.Similar to the structure of extracellular matrix (ECM): 

The unique microstructure of Electrospun Nanofbers scaffolds resembles the nano-network structure of natural extracellular matrix. This promotes the adhesion, growth and migration of fibroblasts, which in turn promotes the formation of new skin tissue at the wound site.

2.Gas exchange and absorption of wound exudate: 

The porous nature of Electrospun Nanofbers scaffolds promotes gas exchange and absorption of wound exudate, creating an optimal microenvironment for cell growth, proliferation, adhesion, migration and differentiation.

3.Controlled drug release:

Electrospun Nanofbers scaffolds provide the ability to load biologically active factors or drugs, such as antibiotics, anti-inflammatories and hypoglycemic agents, enabling targeted delivery of wound healing agents to accelerate the healing process.

4.Increased surface area for cell adhesion:

Nanoscale scaffold fibers increase the surface area for cell adhesion, which is critical for promoting wound healing.

5.Vessel formation and collagen accumulation: 

Electrospun Nanofbers scaffolds promote vascularization, collagen accumulation and normal physiological function, which is essential for controlling the deterioration process of diabetic wounds and promoting wound healing

Multifunctional metal-organic frame fiber stent for antibacterial, anti-inflammatory and rapid hemostasis in diabetic wounds

Taxifolin (TAX) was loaded onto cyclodextrin metal-organic frameworks (CD-MOFs), which were then loaded onto polycaprolactone (PCL) scaffolds by the electrospinnig machine technique to construct multifunctional electrospun fibrous membranes (EFMs) with antimicrobial, anti-inflammatory, hemostatic, and wound exudate-absorbing properties. The resulting EFMs have a hydrophilic surface that facilitates wound adhesion and enhances their hemostatic properties. By aggregating wound exudate and triggering the cascade release of TAX, it reduces wound bacterial infection and decreases the expression of inflammatory factors. This also promotes collagen deposition, vascular regeneration, and contraction and migration of myofibroblasts, facilitating wound tissue remodeling and repair.

Schematic diagram of electrospinnig machine

Originallink: https://doi.org/10.3389/fbioe.2024.1354286