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Conventional wound dressings do not keep the wound moist, do not promote wound healing, and cause secondary damage to the wound when changing the dressing. Therefore, their performance is often poor. electrospun nanofibers for wound dressings have good absorption properties, breathability and comfort, which not only help to promote wound healing, but also prevent infection.
In this study, Electrospun Nanofbers were prepared by coaxial electrostatic spinning with a unique “core/sheath” structure, with a shell layer consisting of copper peroxide nanoparticles (CuO2), polyvinylpyrrolidone (PVP), and polycaprolactone (PCL), and a core layer consisting of PCL. Upon exposure to the moist internal environment of the wound, the PVP within the core layer gradually decomposed to release the embedded nano-CuO2. This resulted in the release of H2O2 and Cu2+ ions through a chemical kinetic reaction induced by the weakly acidic wound microenvironment, such as diabetes mellitus and bacterial infections, subsequently triggering a Fenton-like reaction to produce -OH for antimicrobial purposes, and the release of copper ions to subsequently inhibit inflammation, and to promote angiogenesis. Meanwhile, the dissolution of PVP in Electrospun Nanofbers formed a unique surface pattern of nanogrooves, which provided the required cell-guiding function for accelerated skin regeneration.
Successful development of radial Electrospun Nanofbers patches for wound management, inspired by the branching structure of “Wanglian”
Inspired by the radial branching structure of the water lily plant, Kinglily, the researchers propose a programmable strategy to construct radially assembled Electrospun Nanofbers patches with rapid deployment properties, robust rupture load-bearing capacity, which could facilitate their application in joint trauma with limb movement. In addition, the patch will be endowed with “on-demand” anti-inflammatory drug delivery in the inflammatory microenvironment due to matrix metalloproteinase MMP-9-triggered degradation of the GelMA coating, while a “center-periphery” gradient change of stromal cell-derived factor (SDF1α) can be used to stimulate MSC recruitment toward the lesion site. These properties make radially assembled Electrospun Nanofbers a promising material for wound healing and other regenerative medicine applications.
Taxifolin (TAX) was loaded onto cyclodextrin metal-organic frameworks (CD-MOFs), which were then loaded onto polycaprolactone (PCL) scaffolds by the electrospinnig machine technique to construct multifunctional electrospun fibrous membranes (EFMs) with antimicrobial, anti-inflammatory, hemostatic, and wound exudate-absorbing properties. The resulting EFMs have a hydrophilic surface that facilitates wound adhesion and enhances their hemostatic properties. By aggregating wound exudate and triggering the cascade release of TAX, it reduces wound bacterial infection and decreases the expression of inflammatory factors. This also promotes collagen deposition, vascular regeneration, and contraction and migration of myofibroblasts, facilitating wound tissue remodeling and repair
Originallink: https://doi.org/10.1016/j.cej.2023.147262
https://doi.org/10.1002/adfm.202109833
https://doi.org/10.1002/smll.20230510
