Electrospining Machine:Ecotopes of Electrospun Nanofbers with Long-lasting Immunomodulatory Properties Promote Functional Remodeling of Cardiovascular Tissues

Background

Recently, Prof. Zhu Tonghe's team at Shanghai University of Engineering, in collaboration with Dr. Xu Chen's team at Fudan University, has developed scaffolds combining functional remodeling and long-term anti-inflammatory response, and Electrospun Nanofbers have made a breakthrough in repairing damage to the cardiovascular system. The related research results, titled “ Durable Immunomodulatory Nanoffber Niche for the Functional Remodeling of Cardiovascular Tissue,” were published in the journal ACS Nano

The main points of this paper

1.A durable immunomodulatory Electrospun Nanofbers was developed for functional remodeling of cardiovascular tissues.

2.Electrospun Nanofbers combine biocompatibility and a durable anti-inflammatory response to repair damage to the cardiovascular system by promoting cell infiltration and tissue remodeling.

3.The researchers designed two variants of Electrospun Nanofbers for use in vascular scaffolds and cardiac patches, respectively, and demonstrated their therapeutic effects through in vivo experiments.

4.These findings provide important insights into the recovery of myocardial tissue and offer new directions for progress in the field of cardiovascular tissue repair.

How do Electrospun Nanofbers promote cell infiltration and tissue remodeling, and what are the implications of this for promoting myocardial tissue recovery?

Electrospun Nanofbers gradually disintegrate with the continuous release of salvianic acid A (SA), inhibiting the migration and chemotaxis of inflammatory cells while increasing the expression of angiogenic genes. This creates a microenvironment conducive to cell infiltration and tissue remodeling and promotes recovery of myocardial tissue.Electrospun Nanofbers also provide mechanical support, reducing mechanical stress on the heart wall and promoting synchronized myocardial movement between infarcted and non-infarcted areas. In addition, the sustained release of salvianic acid A molecules by Electrospun Nanofbers for at least 120 days ensures stable release and bioactivity of SA, which can effectively address the core challenge of poor clinical outcomes of current degradable polymer stents. These findings suggest that Electrospun Nanofbers have great potential as multifunctional agents in repairing cardiovascular tissues.

Key findings and insights presented in this review include:

1.Electrospun Nanofbers scaffold has good biocompatibility and degradability.

2.HUC-MSCs were able to proliferate and differentiate into cardiomyocytes on Electrospun Nanofbers scaffolds.

3.After implantation of Electrospun Nanofbers scaffolds, the myocardial function of rat MI model was significantly improved.

Originallink: https://doi.org/10.1021/acsnano.3c09692