Background

The core-sheath structure of Electrospun Nanofbers offers the advantage of dual drug delivery: the core and sheath layers can carry different drugs, facilitating synergistic treatment against chemotherapy resistance. This approach minimizes patient discomfort associated with the administration of multiple drugs.Electrospun Nanofbers not only transport drugs, but also integrate metal particles and targeting compounds, allowing chemotherapy to be combined with magnetotherapy and thermotherapy for comprehensive cancer treatment.

The main points of this paper

1.Electrospun Nanofbers preparation technique for various cancers was studied.

2.Electrospun Nanofbers drug delivery method is introduced.

3.The broad prospect of Electrospun Nanofbers in cancer treatment is envisioned.

What are the advantages of drug-carrying Electrospun Nanofbers in cancer therapy?

1.Sustained and controlled drug release to provide local therapy for different tumor types.

2.Nuclear sheath structure allows dual drug loading and promotes synergistic therapy to counteract chemotherapeutic drug resistance.

3.Reduce patient discomfort associated with multi-drug administration.

4.Integration of metal particles and targeting compounds to achieve an integrated cancer treatment combination of chemotherapy with magnetotherapy and thermotherapy.

Potential for customized drug release performance based on layer thickness for precise control of drug release dynamics.

Key findings and insights presented in this review include:

1.Chemotherapeutic drug resistance remains a major challenge in cancer treatment, and electrospinnig machine technology offers a promising approach to address this challenge.

2.Drug-carrying Electrospun Nanofbers provide sustained and controlled drug release to achieve local therapy for different tumor types.

3.The nucleus-sheath structure of Electrospun Nanofbers allows for dual drug loading and promotes synergistic therapy to counteract chemotherapeutic drug resistance.

4.The integration of metal particles and targeting compounds into Electrospun Nanofbers enables the combination of chemotherapy with magnetotherapy and thermotherapy, providing the possibility of comprehensive cancer treatment.

5.The electrospimnimg system can be customized for specific cancer types, enabling precise delivery in different types of cancer.

The potential of Electrospun Nanofbers to mitigate drug-related toxicity and enhance drug delivery efficiency in cancer therapy was emphasized.

Originallink: https://doi.org/10.3390/polym16040504