Electrospinner: Preparation method of PLGA-based sustained-release microparticles and strategy to increase drug loading

Combination of electrospinning technology and PLGA

Drug carrier: PLGA is widely used as a drug carrier due to its biocompatibility, biodegradability and controllable degradation rate. Combined with electrospinning technology, PLGA nanofibers with high specific surface area and high porosity can be prepared, which are conducive to improving the drug loading capacity and controlled release

Application of electrospinning technology in drug release control

Drug loading method: Through electrospinning technology, drugs can be directly dissolved or dispersed in PLGA solution to prepare drug-loaded nanofibers. This technology can be used for a variety of drugs, including anticancer drugs, antibiotics, proteins, DNA and RNA, etc.

Drug release performance: PLGA nanofibers prepared by electrospinning technology can control the drug release rate by adjusting the diameter and morphology of the fiber. Thicker fibers can extend the drug release path and achieve sustained release, while thinner fibers can increase the drug release rate and bioavailability

Advantages of electrospinning technology

Wide sources of raw materials: Electrospinning technology can use a variety of polymers as raw materials, including PLGA, which provides flexibility for the preparation of drug carriers

Biocompatibility and biodegradability: These properties of PLGA make it an ideal drug carrier material, and electrospinning technology further enhances its application in the biomedical field

Technical challenges and progress

Increase drug loading: Traditional PLGA microparticles have the problem of low drug loading, and electrospinning technology improves the drug loading capacity by preparing nanofibers

Controlled release: Electrospinning technology can control the release behavior of drugs by adjusting process parameters (such as voltage, flow rate, and collection distance) to achieve more precise drug delivery

New technologies and methods

Coaxial electrospinning: Through coaxial electrospinning technology, PLGA nanofibers with a core-shell structure can be prepared, in which the core can be a drug and the shell is PLGA. This structure is conducive to protecting the drug and controlling the release

Hydrogel template method: PLGA microparticles with high drug loading and high incorporation efficiency can be prepared using the hydrogel template method, which is suitable for small molecules and biological preparations

Conclusion

The combination of electrospinning technology and PLGA provides an effective solution for drug carriers and controlled release. Through electrospinning technology, PLGA nanofibers with high specific surface area and high porosity can be prepared, and these characteristics help to improve the drug loading capacity and control the release. In addition, electrospinning technology also allows the precise control of drug release behavior by adjusting process parameters, which provides the possibility for personalized drug delivery. With the further development of technology, electrospinning technology has broad application prospects in the field of drug delivery.

Electrospinning Nanofibers Article Source:

https://sci-hub.ren/10.3389/fphar.2016.00185