Electrospinner: Preparation of polymer-based drug sustained-release micro-nanoparticles by improved coaxial electrostatic spraying

Background

Bipolar release nanomaterials

Bipolar release nanomaterials combine the advantages of fast release and slow release, which can quickly eliminate discomfort symptoms while slowly and continuously releasing drugs in the body, prolonging the drug action time, reducing the number of dosing times, and improving the stability of drug treatment. This release mechanism is of great significance for improving drug efficacy and patient compliance

Application of electrospinning technology in drug delivery

Electrospinning technology has become a research hotspot in the field of drug controlled release because it can prepare micro-nano fibers. This technology helps to improve the solubility and bioavailability of drugs, and can achieve sustained and controlled release of drugs

The following are several key applications of electrospinning technology in the field of drug delivery

Transdermal and mucosal drug delivery: Electrospinning technology can increase the cell contact area. When using polymer materials with good biocompatibility, it is very suitable for cell proliferation, so it is widely used in transdermal and mucosal drug delivery

Tissue engineering: Electrospinning fibers can be used to prepare medical textiles and repair tissue engineering scaffolds due to their high specific surface area and porous structure

Drug loading and application: Electrospinning technology can achieve controlled release of drugs, and summarizes the influencing factors and drug loading methods of electrospinning drug-loaded fibers in drug release

Core-shell structure: The development of electrospinning fiber technology such as core-shell structure makes it possible to apply it to sustained and controlled release of drugs

Coaxial electrospraying technology

Coaxial electrospraying technology is an electrohydrodynamic technology that can simply and efficiently prepare polymer microspheres with core-shell structure. This technology has unique advantages in the preparation of drug carriers, such as the ability to encapsulate hydrophilic and hydrophobic drugs, effectively control the particle size of electrosprayed particles, and is suitable for large-scale preparation of polymer particles. The core-shell structured nanoparticles prepared by coaxial electrospraying technology have good stability and their size remains unchanged after one week of storage. By changing the injection speed of the core layer solution, core-shell structured nanoparticles of different particle sizes can be prepared

Conclusion

In summary, electrospinning technology and coaxial electrospraying technology show great potential in the field of drug delivery. These technologies can provide a variety of drug release effects to meet different therapeutic needs. With the further development and optimization of the technology, they are expected to play a more important role in future drug delivery systems.