Electrospinner: Progress in the application of electrospun nanofiber membranes in dermatology

Research background

Importance of skin: Skin is a major organ of the human body and has a protective function to prevent the invasion of foreign substances.

Effects of skin damage: Injury or infection can damage the protective layer of the skin, leading to various skin diseases.

Tissue regeneration: The key process of repairing damaged skin, including four stages: hemostasis, inflammation, proliferation and remodeling.

Application of nanotechnology: Targeted treatment of skin diseases by drug loading using nanoparticle systems and nanofiber membranes.

Carbohydrate polymers: Such as chitosan and alginate, which show potential in nanodelivery systems due to their adhesive properties.

Nanodelivery systems: Including metal nanoparticles, liposomes, etc., for precise delivery of active compounds to the skin.

Nanofiber manufacturing technology: Involving electrospinning, phase separation and other technologies, the prepared nanofiber membranes have significant antibacterial properties and wound healing effects.

Abstract

Electrospinning method: A variety of high-performance and multi-purpose nanofiber membranes have been successfully prepared.

Application of nanofiber membranes: As drug carriers, they have attracted attention due to their antibacterial properties and ability to heal wounds.

Skin disease treatment: Nanofibrous membranes have potential in treating wounds, fungal infections, skin discoloration disorders, dermatitis, and skin cancer.

Analysis

Technical advantages: Electrospinning technology can prepare nanofibrous membranes with high porosity and high surface area, which helps to improve drug delivery efficiency and biocompatibility.

Therapeutic potential: Nanofibrous membranes show great potential in the treatment of skin diseases, especially in antibacterial and wound healing.

Challenges and opportunities: Although electrospinning technology has advantages in drug delivery, large-scale production and improved cell permeability are still technical challenges that need to be overcome.

Future directions: Research and development of improved electrospinning technology, as well as exploration of new polymer matrices and drugs, to improve the effectiveness and commercialization potential of nanofibrous membranes in the treatment of skin diseases.

Conclusion

Electrospinning technology: Technology for the effective production of nanofibers and high-porosity nanofibrous membranes.

Drug delivery: Various drugs can be added to electrospun nanofibers to achieve controllable and sustained drug delivery.

Therapeutic effects and toxicity: Electrospinning technology can improve therapeutic effects and reduce toxicity levels.

Applications of Nanofiber Membrane: Applications in areas such as biosensors, wound healing, tissue regeneration, and drug delivery.

Challenges: There are challenges in large-scale production of nanofibers with desired properties, including limitations of traditional electrospinning methods and cell penetration issues.