Electrospinner: Research progress of electrospun nanofiber burn dressings

Research background

Importance of skin: Skin is the largest organ in the human body. Burns are a form of skin damage and may be caused by a variety of factors.

Healing of burn wounds: The healing process of burn wounds is complex, including four stages: hemostasis, inflammation, cell proliferation and tissue remodeling.

Problems with traditional skin transplantation: Autologous skin transplantation has limited donors and immune rejection problems.

Multifunctional wound dressings: With the development of biotechnology, the emergence of multifunctional wound dressings and nanofiber scaffold materials has alleviated the problem of skin transplantation.

Limitations of traditional dressings: Traditional dressings do not have anti-infection ability and are prone to adhesion to the wound, causing secondary damage.

Characteristics of ideal dressings: Ideal dressings should be able to absorb exudate, provide a moist environment, have good air permeability, protect the wound, and have good biocompatibility and degradability.

Application of nanofibers: Nanofibers are increasingly used in wound dressings due to their nanoscale structure and properties similar to natural extracellular matrix.

Abstract

Challenges of burns: Burns are a global public health issue. Traditional dressings have a single function and cannot meet the needs.

Prospects of electrospinning: Electrospinning technology shows promise in the development of advanced wound dressings, and electrospun nanofibers have the characteristics of promoting wound repair and preventing infection.

Analysis

Technical advantages: Electrospinning technology is widely used in the preparation of nanofibers due to its advantages such as low cost, high efficiency and simple operation.

Dressing characteristics: The ideal dressing needs to balance absorbency, breathability, protection and biocompatibility, and nanofiber dressings show advantages in these aspects.

Challenges and opportunities: Although nanofiber dressings show potential in burn treatment, they still face challenges of microbial infection and persistent inflammation, and it is necessary to select appropriate dressings.

Future direction: It is necessary to further improve the preparation method of nanofibers and find more bioactive substances to improve the treatment effect and reduce costs. At the same time, a large number of clinical trials are needed to prove the effectiveness and safety of nanofiber dressings.

Conclusion

Application of nanofiber dressings: Nanofiber dressings are often used in burn wound treatment and show great potential for promoting wound healing.

Advances in electrospinning technology: Technological advances have brought about a variety of electrospinning methods, such as blended electrospinning, emulsified electrospinning, etc., which can control the rate of drug release.

Polymer selection: The polymers used for electrospinning nanofibers, including natural polymers and synthetic polymers, as well as their advantages and disadvantages, are reviewed.

Encapsulation of bioactive substances: Nanofiber dressings are bioactive by adding antibiotics, natural active substances, nanoparticles, etc., to prevent bacterial infection and accelerate wound healing.