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Electrospinning technology is widely used in regenerative medicine because of its advantages such as its ability to simulate the natural structure of the extracellular matrix. This technology can produce nanofibers with high porosity and high specific surface area, which are conducive to cell attachment, proliferation and differentiation, and are particularly important for tissues such as MTJ that require fine structure regeneration.
Electrospinning technology can be applied to a variety of natural polymers and synthetic polymers to prepare fibers. In MTJ regeneration, it is key to select suitable materials to meet specific mechanical properties and degradation time, which helps to build a scaffold that can simulate the biological composition and physicochemical properties of MTJ.
The nanofiber scaffolds prepared by electrospinning technology have a high specific surface area, which allows the scaffold to carry and release a variety of biochemical substances such as drugs, proteins, and nucleic acids, which is of great significance for regulating the pathological microenvironment after MTJ damage and promoting cell behavior.
Electrospinning technology can be used to construct non-woven mats of different biomaterials with physical dimensions similar to the natural extracellular matrix, that is, non-woven mats with nano-sized geometric shapes. This is particularly important for the regeneration of tissues such as MTJs, which have complex structures and need to accurately simulate their natural structures.
The clinical application of electrospinning technology in the biomedical field still needs further research, especially in in vivo research. For MTJ regeneration strategies, future work may include applying scaffolds prepared by electrospinning technology to in vivo models to evaluate their effectiveness and safety in actual biological environments.
The combination of electrospinning technology with bioactive molecules (such as mesenchymal stem cells and recombinant protein Klotho) provides sufficient mechanical support for the structural and functional regeneration of MTJs and regulates the pathological microenvironment after MTJ injury. This combination provides a new strategy. The scaffolds prepared by electrospinning technology can be used as carriers of cells and bioactive molecules to promote the regeneration of MTJs.
In summary, electrospinning technology shows great potential in MTJ regeneration strategies, especially in simulating the complex biological structure of MTJs and providing a suitable microenvironment. Future research needs to further explore the application of electrospinning technology in MTJ regeneration and evaluate its effectiveness in in vivo models.
Electrospinning Nanofibers Article Source:
https://www.science.org/doi/10.1126/sciadv.adm7164
