Electrospinning Device: Bioactive glass nanofibers chimeric self-assembled silk fibroin with antibacterial, anti-osteosarcoma and osteoinductive properties

Background

Hajar Maleki's research team at the University of Cologne prepared bioactive glass nanofibers 70SiO2-25CaO-5P2O5 (BGNF) by electrospinning technology. These nanofibers were integrated into a self-assembled silk fibroin (SF) and tannic acid (TA) gel matrix to form a multifunctional aerogel-based 3D composite scaffold.

Role of BGNF in bone tissue engineering

Electrospinning-prepared BGNF plays an important role in the mechanical strength, biomineralization bioactivity and enhanced biocompatibility of the scaffold due to its bioactivity and mechanical properties. The addition of BGNF supports the mechanical properties of the gel, which is essential for the stability and functionality of the scaffold in bone tissue engineering.

Application of electrospinning equipment in 3D printing

The dynamic characteristics of the coordinated ligand-metal bonds in the self-assembled SFO matrix mentioned in the study enable the SFO-TA-BGNF composite gel to be extruded through the nozzle, facilitating 3D printing into a scaffold with excellent shape fidelity. This shows that electrospinning equipment plays a key role in the preparation of bio-inks that can be used for 3D printing.

Photothermal antibacterial and anti-osteosarcoma properties

The developed  composite aerogels exhibited near-infrared-triggered photothermal antibacterial and in vitro photothermal anti-osteosarcoma properties, which were due to the abundant near-infrared-active catechol groups in the gel matrix. This photothermal effect has potential application value in osteosarcoma treatment.

Enzymatic biodegradability

The designed aerogels exhibited enzymatic biodegradability in both the ceramic and organic phases, which is very important for the final degradation and absorption of the scaffolds in bone tissue engineering, which can reduce the risks and complications of surgical removal of the scaffolds.

Clinical application potential

These multifaceted functions, including antibacterial, anti-osteosarcoma and osteogenic potential, make this composite aerogel material a promising candidate for minimally invasive osteosarcoma treatment, advancing its clinical application prospects.

Summary

In summary, electrospinning equipment played an important role in the preparation of bioactive glass nanofibers used in BTE, and these nanofibers showed excellent performance in 3D printing, photothermal therapy and biodegradability, providing new solutions for bone tissue engineering and osteosarcoma treatment.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acsami.4c00065