Electrospinning Device: Carbon nanotube-reinforced cell-derived silk fibroin scaffolds for bone tissue engineering

Background

Electrospinning technology can produce nano- to micron-fiber scaffolds that mimic the extracellular matrix (ECM). These scaffolds have high porosity and large specific surface area, providing an ideal 3D microenvironment for cell attachment and proliferation. The scaffolds combined with silk fibroin, carbon nanotubes and dCDM prepared by electrospinning technology can improve the mechanical properties and bioactivity of the scaffolds, thereby promoting bone tissue regeneration.

Improvement of mechanical properties

Electrospinning technology can improve the mechanical, biological and degradation properties of electrospun nanofibers through the use of crosslinkers. For example, chemically connecting electrospun nanofibers can enhance the mechanical properties of the scaffold, which is particularly important for bone tissue engineering because bone tissue needs to withstand large mechanical loads.

Controlled drug release

Electrospinning technology can also be used to prepare drug-loaded fibers to achieve sustained or special release effects of drugs, reduce drug toxicity and improve utilization. In bone tissue engineering, this can be achieved by embedding drugs (such as antibiotics or bone growth factors) directly into the scaffold to achieve local drug delivery and promote bone healing.

Promote bone mineralization and cell differentiation

Nanofiber scaffolds prepared by electrospinning can promote bone mineralization and cell differentiation. Studies have shown that electrospun nanofiber scaffolds have natural bone hierarchical structures and porous structures at the nanoscale, and improved composite scaffold materials can promote cell infiltration growth, stem cell differentiation and tissue formation.

Improve the biocompatibility and bioactivity of scaffolds

Scaffolds prepared by electrospinning technology have excellent biocompatibility, which is essential for cell growth and differentiation in bone tissue engineering. The biocompatibility and bioactivity of scaffolds can be further improved by combining electrospinning technology with silk fibroin and other biomaterials.

Manufacturing of 3D structure scaffolds

Traditional electrospinning meshes can only provide 2D architectures, while bone tissue engineering requires 3D structures to simulate natural tissues. In recent years, the manufacture of 3D electrospun scaffolds for bone tissue regeneration has attracted great attention. By combining traditional and coaxial electrospinning with other scaffold manufacturing technologies, 3D structures with the potential to engineer missing human bones can be produced.

Summary

In summary, electrospinning technology has broad application prospects in bone tissue engineering. It can combine materials such as silk fibroin, carbon nanotubes and dCDM to prepare high-performance bone tissue engineering scaffolds, improve mechanical properties, achieve controlled drug release, and promote bone mineralization and cell differentiation, providing an effective solution for bone defect repair and bone tissue regeneration.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1039/D1TB01972D