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Diabetes is a common morbidity characterized by high blood sugar. Long-term diabetes can cause other diseases such as accelerated disease, renal function disease, neuropathy and cardiovascular disease. In recent years, the number of diabetic patients has increased, especially now that insulin is the most commonly used drug for the treatment of diabetes.
Electrospinning technology can prepare nanofiber scaffolds with a structure similar to that of the extracellular matrix (ECM), which can promote the adhesion, growth and migration of fibroblasts, thereby promoting new skin tissue.
The properties of electrospun scaffolds are conducive to gas exchange and the absorption of wound exudate, creating an optimal microenvironment for cell growth, proliferation, migration, migration and secretion.
These scaffolds can be loaded with bioactive factors or drug inflammation, such as antibiotics, anti-drugs and hypoglycemic drugs, to achieve a pause in wound treatment and the treatment process.
The development of insulin-loaded silk protein microneedle patches utilizes the natural polymer material silk protein, which has good solubility and biodegradability, and supports the stable release of insulin in the body without the same reaction.
Electrospinning equipment can be used to prepare nanofibers with specific structures and functions, which can be used as drug carriers, including insulin. Through electrospinning technology, nanofiber dressings with high porosity and high specific reinforcement can be prepared. These dressings can be used as carriers of insulin to promote the sustained release and transdermal barrier of insulin.
Electrospinning technology can also control drug release by adjusting the fiber structure, which is extremely important for the preparation of insulin-loaded silk protein microneedle patches because it can achieve sustained and controlled release of insulin.
The nanofiber scaffolds provided by electrospinning can increase the limit of device cell attraction, which is crucial for promoting wound healing.
These scaffolds can also promote angiogenesis, collagen accumulation and normal physiological functions, which are crucial for controlling the deterioration process of diabetic wounds and promoting wound treatment.
Improving the application of electrospinning technology in diabetic wound treatment shows great potential. It can not only provide a new treatment method, but also achieve therapeutic effects by controlling drug release.
In summary, electrospinning equipment has great application potential and advantages in diabetes treatment, especially in diabetic wound treatment and insulin solution system. Through this technology, efficient solution and controlled release of drugs can be achieved, thereby improving the treatment effect and reducing the pain of patients.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1021/acsbiomaterials.0c00273
