Electrospinning Device: Easy-to-print silk fibroin hydrogel microparticles as injectable long-lasting fillers

Background

Electrospinning is an effective method for preparing nanofibers, which can produce nanofiber materials with high specific surface area and porous structure. In the study of facial fillers, new injectable regenerated silk fibroin (RSF) microparticles were printed using silk hydrogels modified with glycidyl methacrylate, which has something in common with electrospinning technology in preparing high-performance nanofiber materials.

Biocompatibility and durability

Nanofibers prepared by electrospinning technology show good biocompatibility in the biomedical field, especially in tissue engineering, due to their unique physical and chemical properties. Similarly, RSF hydrogel microparticles not only have good biocompatibility, but also facilitate the migration of fibroblasts, which is crucial for facial fillers.

Regulation of mechanical properties

Electrospinning technology can control the mechanical properties of nanofibers by adjusting the process parameters. In the study of RSF hydrogels, the β-sheet content and mechanical properties were adjusted by the number of freeze-thaw cycles, which is similar to the method of adjusting fiber properties by process parameters in electrospinning.

Microparticle uniformity and injectability

Electrospinning technology can produce uniform nanofibers, which is crucial for the injectability of facial fillers. RSF hydrogel microparticles are uniform, with a diameter of about 300-500 μm, which can be adjusted by the pore size of the printing screen, which is similar to the method of controlling fiber diameter by adjusting parameters in electrospinning technology.

Clinical application potential

Nanofibers prepared by electrospinning technology show great potential in clinical applications. RSF hydrogel microparticles have great potential in facial rejuvenation, which indicates that silk fibroin-based nanofiber scaffolds have application prospects in the field of facial fillers.

Promote angiogenesis and tissue regeneration

Nanofibers prepared by electrospinning technology can promote angiogenesis and tissue regeneration. RSF hydrogel microparticles form persistent bulges at the injection site, and tissue sections show blood vessels formed around the microparticles, which echoes the characteristics of electrospun nanofibers promoting angiogenesis and tissue regeneration.

Summary

In summary, the connection between electrospinning technology and silk fibroin-based nanofibrous scaffolds in the field of facial fillers is reflected in the preparation method, biocompatibility, mechanical property regulation, particle uniformity and injectability, and clinical application potential. These connections show that electrospinning technology provides important technical support and theoretical basis for the development of high-performance facial fillers.

Electrospinning Nanofibers Article Source:

https://doi. 10.1039/d3bm01488f