Electrospinning Device: Hydrogel dressing composed of silk fibroin, nano-Ag, and reduced graphene oxide for near-infrared photothermal enhanced antibacterial and skin regeneration

Background

Electrospinning technology can produce materials with antibacterial properties, such as electrospinning-prepared nanofiber structures, which can be loaded with antibacterial agents, such as metal nanoparticles, to provide a long-lasting antibacterial effect. In SF/Ag@rGO hydrogels, the introduction of silver nanoparticles (NPs) provides inherent antibacterial activity, which, combined with near-infrared (NIR)-assisted antibacterial therapy, enhances the therapeutic effect on bacterial infections.

Near-infrared responsiveness

Nanofibers prepared by electrospinning technology can enhance their photothermal properties by doping with near-infrared responsive materials, such as reduced graphene oxide (rGO). The rGO component in SF/Ag@rGO hydrogel produces a photothermal effect under NIR irradiation, which synergizes with the antibacterial activity of silver nanoparticles to effectively inhibit bacterial infection and promote wound healing.

Antioxidant properties

Electrospinning technology can produce nanofibers with antioxidant properties, which can be achieved by loading antioxidants or using antioxidant materials. L-ascorbic acid in SF/Ag@rGO hydrogels endows the hydrogels with antioxidant properties, which helps to alleviate excessive oxidative stress, one of the main factors that delay skin wound healing.

Mechanical properties and tissue adhesion

The nanofibers prepared by electrospinning technology have excellent mechanical properties and tissue adhesion, which are essential for the fixation and effective treatment of wound dressings. SF/Ag@rGO hydrogels exhibit high tissue adhesion and moderate mechanical strength, which are essential for the self-healing ability of dynamic wounds.

Biocompatibility and cell proliferation

Electrospinning technology can prepare nanofibers with good biocompatibility, which is very important for promoting cell proliferation and wound healing. SF/Ag@rGO hydrogels exhibit good biocompatibility and promote cell proliferation, which is a key step in the wound healing process.

Angiogenesis and collagen production

Electrospinning technology can prepare materials with the ability to promote angiogenesis and collagen production, which are essential for wound healing and tissue repair. SF/Ag@rGO hydrogels promote wound healing through angiogenesis, stimulate collagen production, and reduce inflammation, which are key factors in wound healing.

Summary

In summary, the combination of electrospinning technology and silk fibroin provides an effective method in the development of multifunctional wound dressings, which significantly improves the healing effect of infected skin wounds by introducing multiple functions such as antibacterial, antioxidant, and near-infrared responsiveness.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1002/adhm.202400884