Electrospinning Device: Silk fibroin hydrogel: a new tool for promoting nerve regeneration

Background

Electrospinning technology can be used to prepare catheter scaffolds for nerve repair. Studies have shown that gradient-degradable nerve catheter scaffolds were successfully prepared by electrospinning technology and layer-by-layer winding. This technology can be used to prepare silk fibroin-based nerve catheters to provide a suitable microenvironment for nerve regeneration.

Surface modification and microstructure introduction

In order to improve the hydrophilicity of the catheter and use it as a nerve repair scaffold, the surface modification was performed by retaining natural biomaterials such as chitosan on the catheter surface. Similarly, silk fibroin hydrogels can promote the growth of Schwann cells and guide neurite sprouting by introducing micropapillary structures, which is also an important research direction for catheters prepared by electrospinning technology.

Preparation of micro-nanostructures by electrospinning

Electrospinning technology can prepare nanofibers with core-sheath, hollow or porous structures. These structures can be used to create silk fibroin catheters with specific microstructures to induce directional migration and growth of nerve cells.

Preparation of Janus micro-nanofibers

Electrospinning technology has also been used to prepare Janus micro-nanofibers, which have heterogeneous structural characteristics and can be widely used in the field of multifunctional composite materials. This is inspiring for the design of silk fibroin conduits, as the Janus structure can provide different bioactive surfaces to promote the growth of specific types of cells.

Preparation of three-dimensional nanofiber materials

Electrospinning technology can also be used to prepare three-dimensional nanofibrous body materials, which have fluffy structures that can be controlled by adjusting humidity and electric field forces. This structure is particularly important for the preparation of silk fibroin conduits because it can simulate the three-dimensional environment around nerves and provide better conditions for cell attachment and growth.

Application potential of electrospinning technology

Electrospinning technology has a wide range of application potential in achieving the micro-nanoscale directional structural control of Janus fibers. This is an important development direction for silk fibroin-based nerve conduits because it can provide more structural and functional options to promote nerve regeneration.

Summary

In summary, the combination of electrospinning technology and silk fibroin provides new possibilities for the design and preparation of artificial nerve grafts, especially in creating conduits with directional microstructures to promote the directional migration and growth of nerve cells. Through electrospinning technology, silk fibroin-based nerve conduits with specific structures and functions can be prepared, providing new solutions for the repair of peripheral nerve injuries.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1515/ntrev-2021-0002