Electrospinning Device: Piezoresistive MXene/silk nanocomposite hydrogel reconstructs electrical microenvironment to promote bone regeneration

Background

The electrical microenvironment plays an important role in bone repair. Electrical stimulation (ES) can regulate the function of osteoblast-related cells and promote bone regeneration. As an electroactive material, MXene/RSF hydrogel can simulate this electrical microenvironment, thereby promoting bone regeneration.

Preparation and properties of MXene/RSF hydrogel

MXene/RSF hydrogel is prepared by co-assembly technology, using RSF bioencapsulated MXene nanosheets to form a double cross-linked network nanocomposite hydrogel. This hydrogel not only has good electrical activity, but also can be used as a piezoresistive pressure sensor to monitor the electrophysiological microenvironment.

Mechanism of MXene/RSF hydrogel promoting bone regeneration

Direct osteogenesis: MXene/RSF hydrogel can activate the Ca2+/CALM signaling pathway and promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).

Immune microenvironment regulation: ES promotes the polarization of M2 macrophages through MXene/RSF hydrogel, thereby indirectly promoting bone regeneration.

Neovascularization: Sustained improvement of bone regeneration and angiogenesis was observed in MXene/RSF hydrogels under ES, providing nutrition for bone regeneration and increasing the number of target cells.

Application and development trend of electrospinning technology

Electrospinning technology is the most direct and effective method for preparing nanofibers, which is widely used in medicine, environmental protection and other fields. In bone tissue engineering, electrospinning technology can be used to prepare ordered nanofibers, which can be used as scaffolds for bone repair and provide a good cell attachment and growth environment.

Potential combination of MXene/RSF hydrogel and electrospinning technology

The combination of the electroactivity of MXene/RSF hydrogel and nanofibers prepared by electrospinning technology can develop new bone repair materials. This combination can utilize the high specific surface area and porosity of nanofibers prepared by electrospinning technology and the electroactivity of MXene/RSF hydrogel to jointly promote bone regeneration.

Conclusion

MXene/RSF hydrogel provides a unique and promising strategy to promote direct osteogenesis, regulate the immune microenvironment and neovascularization by reconstructing the electrical microenvironment of the bone microenvironment, thereby promoting bone regeneration. The development of electrospinning technology has made it possible to prepare nanofibers with specific structures and functions, which can be combined with MXene/RSF hydrogels to further improve the performance of bone repair materials.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.bioactmat.2022.08.025