Electrospinning Device: Silk nanoparticles generate nanopores in silk membranes for full-thickness wound healing

Background

Silk membranes have shown significant effects in promoting wound epithelialization and skin regeneration in full-thickness wound models due to their excellent mechanical properties, biocompatibility, biodegradability, and low inflammatory response. However, the low permeability of silk membranes limits their use in some applications. Liu Jian et al. solved this problem by generating nanopores in silk membranes treated with methanol or ethanol, which enhanced the air permeability and cell proliferation support of silk membranes.

Application of electrospinning equipment

Electrospinning technology is an important technology for manufacturing micro/nano fiber platforms, which can be used for biomedical scaffolds for tissue engineering repair and regeneration. Electrospun nanofibers have shown great potential in the biomedical field, especially in biosensors, due to their significant porosity, high specific surface area, and excellent load capacity.

Working principle of electrospinning equipment

The working principle of the electrospinning machine is based on the stretching effect of the electric field on the charged droplets. By applying a high voltage, the polymer solution or melt forms a Taylor cone at the nozzle, and the fiber is ejected under the action of the electric field force. This technology can produce nanofibers, which are widely used in filtration, barrier, separation membranes, clothing materials, biomedical materials and other fields.

Application of electrospinning equipment in medicine

Nanofibers prepared by electrospinning have good biocompatibility and drug carrier properties, and are suitable for manufacturing tissue engineering scaffolds, drug sustained release systems and biosensors. These nanofiber materials can be used to manufacture high-performance protective clothing, such as fireproof clothing and bulletproof clothing, due to their excellent mechanical properties and protective properties.

Development trend of electrospinning technology

Electrospinning machines will be optimized and innovated in equipment structure, control system and process parameters to improve production efficiency, reduce energy consumption and improve product quality. In the future, electrospinning machines will support the production of more types of polymer materials and nanomaterials to meet the requirements of fiber material performance in different fields.

Conclusion

Electrospinning technology shows great potential in the preparation of nanofibers with specific structures and functions, especially in the biomedical field. Nanofibers prepared by electrospinning equipment can enhance the permeability of silk membranes and improve their application effect in skin damage repair. In addition, the development of electrospinning technology will promote the development of more innovative products and provide more solutions for tissue engineering and regenerative medicine.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acs.biomac.0c01411