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This study developed a new type of photo-crosslinked SF/IL hydrogel, namely SF-IMA/PIL hydrogel, by modifying silk chains with 2-isocyanoethyl methacrylate (SF-IMA) in a specific ionic liquid with unsaturated double bonds. This method achieves the preparation of hydrogels through chemical crosslinking and physical crosslinking (β-folding formation of SF) triggered by UV light.
SF-IMA/PIL hydrogel has significant ionic conductivity between room temperature and -50°C and water retention over a wide relative humidity range, which is a unique advantage of ionic liquids. In addition, static and dynamic mechanical tests showed that the hydrogel retained good elasticity at -50°C and showed its stiffness transition temperature between -100 and -70°C.
Due to its low-temperature elasticity, conductivity and water retention, SF-IMA/PIL hydrogel has become an excellent substrate for flexible devices. Especially at sub-zero temperatures, the conductivity and water retention of SF-IMA/PIL hydrogels make them promising for application in water electrolysis devices.
Electrospinning technology can be used to prepare silk fibroin-based nanofibers, which show great potential in the fields of tissue engineering and wound healing due to their unique properties. Although the SF-IMA/PIL hydrogels in this study were prepared by photocrosslinking, electrospinning technology can be used to prepare silk fibroin-based nanofiber scaffolds, which can be further combined with hydrogels to form composite materials with specific structures and functions.
Research progress on electrospinning fibers as periodontal drug delivery systems shows that electrospinning technology has important application value in dentistry. Silk fibroin nanofibers prepared by electrospinning technology can be used for the delivery of periodontal drugs, which complements the preparation and application fields of SF-IMA/PIL hydrogels.
In summary, the preparation method, characteristics and applications of SF-IMA/PIL hydrogels demonstrate the potential of silk fibroin in flexible electronic devices and biomedical materials. The application of electrospinning technology provides new possibilities for the development of silk fibroin materials, especially in the preparation of nanofiber scaffolds with specific structures and functions. These research results provide a new perspective for the application of silk fibroin in the biomedical field and lay the foundation for future clinical applications.
Electrospinning Nanofibers Article Source:
https://pubs.acs.org/doi/10.1021/acsami.3c15712
