Electrospinning Device: Silk fibroin-based ureteral stent with sustained drug release function

Application of drug-loaded ureteral stents in the treatment of ureteral stenosis

Drug sustained release performance: The drug-loaded ureteral stent has good drug sustained release performance. The cumulative release rate of rapamycin and paclitaxel in the drug-loaded silk fibroin membrane ureteral stent samples on the 30th day reached about 80%, which can continuously release drugs and inhibit the excessive proliferation of fibroblasts and smooth muscle cells.

Anti-stenosis effect: The stent can inhibit the excessive growth of fibroblasts and the excessive deposition of collagen, thereby achieving the purpose of anti-stenosis. In vivo biocompatibility shows that the drug-loaded ureteral stent avoids complications such as inflammation and restenosis by reducing the excessive deposition of collagen fibers.

Biocompatibility: Compared with free drug-loaded stents, the drug-loaded stents have fewer inflammatory cell aggregates, lighter immune responses, better biological affinity, and show good biocompatibility.

Application of electrospinning equipment in the preparation of drug-loaded ureteral stents

Preparation of nanofiber structure: Electrospinning equipment can prepare nanofibers with specific structures and properties. These nanofibers can be used to construct a more sophisticated ureteral stent structure and further optimize its performance. For example, nanofibers prepared by electrospinning technology can be composited with drug-loaded ureteral stents to form composite materials with better mechanical properties and drug sustained release properties.

Regulating the microstructure of the stent: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of the drug-loaded ureteral stent to be precisely regulated, thereby better meeting the needs of drug sustained release and tissue compatibility.

Loading drugs: Electrospinning equipment can prepare drug-loaded nanofiber stents. For example, drugs such as rapamycin and paclitaxel are loaded into silk protein nanofibers, and by controlling the release rate, the drug can be continuously applied to the ureteral stenosis site, further improving the anti-stenosis effect.

Summary

In summary, drug-loaded ureteral stents show good application effects in the treatment of ureteral stenosis, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, nanofiber scaffolds with specific structures and properties can be prepared, further optimizing the performance of drug-loaded ureteral stents and improving their application effect in the treatment of ureteral stenosis.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acsbiomaterials.3c00781