Copyright © 2022 Foshan MBRT Nanofiberlabs Technology Co., Ltd All rights reserved.Site Map
Promote cell adhesion and proliferation: The specific amino acid sequence on the surface of silk fibroin hydrogel can bind to cell surface receptors, activate intracellular signal transduction pathways, and thus promote cell proliferation. The silk fibroin nanofiber scaffold prepared by electrospinning equipment has a high specific surface area, which is conducive to the adhesion of cells on its surface.
The pore structure of silk fibroin hydrogel provides a channel for cell migration, allowing cells to enter the damaged area smoothly. The nanofiber scaffold prepared by electrospinning technology can better mimic the natural extracellular matrix in microscopic size and distribution structure, providing seed cells with a reticular support structure similar to the extracellular matrix of cartilage cells, which is conducive to the repair of cartilage tissue.
Silk fibroin hydrogel can be used as a carrier to slowly release growth factors such as TGF-β1 and BMP-2, which can induce mesenchymal stem cells to differentiate into chondrocytes. Electrospinning equipment can prepare nanofiber scaffolds loaded with bioactive molecules. By adjusting the spinning parameters, gradient synthesis can be achieved to obtain fiber membranes with different diameters and different arrangement distributions, thereby achieving the delivery of bioactive substances.
Silk fibroin hydrogel has excellent mechanical properties. Its strength and elastic modulus are similar to those of natural cartilage, and it can provide necessary mechanical support for repaired cartilage during joint movement. Electrospinning technology can prepare nanofibers with specific mechanical properties. These fibers can be used to construct more sophisticated scaffold structures and further optimize the performance of silk fibroin hydrogel.
Silk fibroin hydrogel can stimulate chondrocytes to synthesize more extracellular matrix components, such as type II collagen and proteoglycans. Nanofiber scaffolds prepared by electrospinning equipment can promote the deposition of extracellular matrix, and their high specific surface area is conducive to the formation of extracellular matrix.
Preparation of nanofiber scaffolds: Electrospinning equipment can prepare silk fibroin nanofibers with specific structures and properties. These fibers can be used to construct more sophisticated scaffold structures and further optimize the performance of silk fibroin hydrogels. For example, silk fibroin nanofibers prepared by electrospinning technology can be compounded with silk fibroin hydrogels to form composite materials with better mechanical properties and biocompatibility.
Regulating the microstructure of the scaffold: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of the silk fibroin hydrogel scaffold to be precisely regulated, thereby better meeting the needs of cartilage repair.
Loading bioactive substances: Electrospinning equipment can prepare nanofiber scaffolds loaded with bioactive molecules. By adjusting the spinning parameters, gradient synthesis can be achieved to obtain fiber membranes of different diameters and different arrangement distributions. This allows silk fibroin hydrogels to more effectively deliver bioactive substances such as growth factors and promote the proliferation and differentiation of chondrocytes.
In summary, silk fibroin hydrogel plays an important role in cartilage repair, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, silk fibroin nanofiber scaffolds with specific structures and properties can be prepared, further optimizing the performance of silk fibroin hydrogel and improving its effect in cartilage repair.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1016/j.bioactmat.2024.01.015
