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Silk fibroin microspheres are prepared from regenerated silk fibroin obtained by chemical separation and removal of other substances from sericin. This material has good biocompatibility, excellent mechanical properties and biodegradability, making it popular in the food field. Silk fibroin nanoparticles have the characteristics of small size, controlled degradation and release, and can be used as a delivery system for bioactive ingredients. They are also often used in food packaging.
After encapsulating naringin in silk fibroin microspheres, the crystal structure of naringin did not change, and there were only a few diffraction peaks in the microspheres, indicating that most of the naringin was encapsulated in an amorphous state. Intermolecular interactions make naringin-SA-microspheres form a stable state.
Compared with free naringin, the water solubility of encapsulated naringin increased, which can be explained by the transition from crystalline to amorphous state; the results are consistent with DSC and XRD. The release curves of naringin in microspheres with different pH values showed that with the increase of pH value, the cumulative release rate of naringin showed a trend of first increasing and then decreasing, and the cumulative release of naringin within 12 hours was as high as 60%.
The DPPH radical scavenging activity of naringin and microspheres was evaluated as antioxidant capacity. The scavenging rate of microspheres continued to increase with the increase of concentration, and it was predicted that it might reach or exceed the Vc level of 6.3 mg/mL.
The darkening of the microspheres may be caused by the decrease of water content of the microspheres at high temperature. Due to the hygroscopicity of naringin powder, agglomeration of free naringin was observed at high temperature. These results indicate that encapsulation has a protective effect on naringin, and the microspheres can maintain the stability of naringin for long-term storage.
Preparation of silk fibroin microsphere/electrospun nanofiber composite carrier: Studies have shown that electrospinning technology can be used to encapsulate drug-loaded microspheres (such as silk fibroin microspheres) into electrospun nanofibers to form a composite carrier. This composite carrier can solve the problem of "burst release" in the early stage of drug release and provide a new carrier form for the field of drug delivery.
Application of electrospinning technology in the food field: The application of electrospinning technology in the food field includes the embedding of active substances, food testing, new food development and food additives. Silk fibroin, as a natural protein, has good biocompatibility and biodegradability. It can be processed into nanofiber membranes by electrospinning technology for food packaging or as a carrier of food additives.
In summary, the connection between electrospinning technology and silk fibroin microspheres is that they can be used together to prepare new food carriers and packaging materials, improve the stability and sustained release effect of active ingredients in food, and develop new foods and food additives. These applications demonstrate the potential and importance of electrospinning technology in food science
Electrospinning Nanofibers Article Source:
https://doi.org/10.1007/s13197-024-06000-5
