Electrospinning Device: Vegetarian protein leads to pancreatic islet health and promotes the natural transformation of anti-inflammatory macrophages

Background

Silk fibroin is a natural protein with excellent performance, good biocompatibility and biodegradability, and can be easily processed into a variety of forms, including microspheres and nanofibers. Through electrospinning technology, drug-loaded microspheres can be encapsulated in electrospun nanofibers to form silk fibroin microsphere/electrospun nanofiber composite carriers, which provides a new method to solve the problem of "burst release" in the early stage of drug release.

Controlling early innate immune cell response

Electrospun fiber meshes are widely used in tissue repair because they can guide a large number of cellular responses, including phenotypic differentiation and tissue maturation. A key factor that determines the final biological outcome of mesh-based regeneration strategies is the early innate immune response after implantation. The effects of specific fiber/mesh properties and mechanical stimulation on the response of early innate immune regulators (i.e., neutrophils, monocytes, and macrophages) can promote matrix characteristics of anti-inflammatory immune phenotypes and associate this response with pro-regeneration.

Application of electrospinning technology in the food field

Nanofiber membranes prepared by electrospinning technology have the advantages of high specific surface area, good continuity, and strong functionality, and are widely used in medicine, energy, food and other fields. In the food field, electrospinning technology can be used for active substance embedding, food testing, food additives, etc., providing new solutions for food safety and nutrition.

Development of silk nonwoven materials

The schematic diagram of the electrospinning process of silk protein shows that silk fibers can be dissolved in solutions such as formic acid. The silk nonwoven materials obtained by electrospinning have the characteristics of ultra-thinness, high porosity, and good surface morphology. They have great application value in biomedical applications such as wound dressings, biological scaffolds, tissue engineering, drug delivery, and air filtration.

Immunomodulatory network design

The strategy of controlling the early innate immune cell response based on electrospun fibers can promote the design of immunomodulatory networks for robust tissue repair. This is particularly important for immunoregulation after islet transplantation, because islet transplantation requires controlling immune responses to improve the success rate of transplantation.

Summary

In summary, the combination of electrospinning technology with mulberry silk and non-mulberry silk can not only be used to prepare new drug carriers, but also play an important role in immunoregulation and tissue repair, especially in the field of islet transplantation and food.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.biomaterials.2018.09.037