Electrospinning Device: Silk fibroin nanofiber hydrogel: a new dressing for chronic wound infection

Background

Electrospinning technology can prepare drug-loaded nanofibers to achieve ideal encapsulation and loading of drugs, and play a good therapeutic role by adjusting the release of drugs by the scaffold. The supramolecular hydrogel dressing developed by the team of researcher Chen Jing of Shandong University enhances the antibacterial properties of the dressing by incorporating Ga ions into the hydrogel matrix and utilizing the antibacterial properties of Ga ions.

Promote wound healing

The nanofibers prepared by electrospinning technology can promote cell adhesion and growth and accelerate wound healing due to their high specific surface area and porous structure. Puerarin in supramolecular hydrogel dressings has natural antioxidant properties, which can alleviate oxidative stress caused by excessive ROS and promote the transition of infected wounds from the inflammatory phase to the proliferative phase.

Biocompatibility and safety

The nanofibers prepared by electrospinning technology have good biocompatibility and can be safely used for wound treatment. Silk fibroin (SF) in supramolecular hydrogel dressings improves the hemolysis of puerarin, making it safe for wound treatment.

Antioxidant and anti-inflammatory properties

Electrospinning technology can prepare nanofibers with antioxidant properties for reducing inflammatory responses. Puerarin in supramolecular hydrogel dressings exhibited excellent free radical scavenging activity and ROS scavenging ability, indicating that its excellent antioxidant properties can be used as an ideal antibacterial dressing.

Hemostatic properties

Electrospinning technology can prepare nanofibers with hemostatic function for controlling wound bleeding. Supramolecular hydrogel dressings showed rapid hemostasis in a mouse liver bleeding model, and the total blood loss was significantly reduced.

Tissue engineering and regenerative medicine

Electrospinning technology is widely used in tissue engineering to prepare biological scaffold materials to provide necessary support and guidance for cells. The double nanofiber structure of supramolecular hydrogel dressings effectively enhances the mechanical strength and thermal stability of the obtained supramolecular hydrogel, providing a good scaffold for wound repair.

Summary

In summary, electrospinning technology and supramolecular hydrogel dressings are closely related in antibacterial, wound healing, biocompatibility, antioxidant, hemostasis and tissue engineering. Both technologies take advantage of the unique advantages of nanofibers and provide new strategies and material options for the treatment of infected wounds.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1002/adhm.202400071