Electrospinning Device: Fiber-reinforced silk fibroin microneedle patch for improving tissue adhesion in diabetic wound infection

Background

Electrospinning technology is an effective method for preparing nanofiber materials. Its manufacturing equipment is simple, low-cost, and a wide variety of spinnable materials are available. Although the SCEMN patch developed by the team of Associate Professor Lu Fei of Southwest University is not prepared by electrospinning technology, it also uses nano-level fine structures to enhance its performance, which is similar in size to the nanofibers prepared by electrospinning technology.

Application in the biomedical field

Electrospinning technology has been widely used in the biomedical field, especially in tissue engineering scaffolds, drug release, cell culture, etc. As a new type of microneedle patch, the application of SCEMN patch in the treatment of diabetic wound infection also reflects the potential of biomedical materials in promoting wound healing.

Improve tissue adhesion and wound healing

Nanofibers prepared by electrospinning technology can promote cell adhesion and growth and accelerate wound healing due to their high specific surface area and porous structure. The SCEMN patch enhances mechanical strength and viscosity by introducing chitosan fibers, increases the ability to physically entangle with tissues and maintain shape, thereby effectively improving the healing of diabetic wounds.

Antioxidant and antibacterial properties

Electrospinning technology can prepare nanofibers with antioxidant and antibacterial properties for reducing inflammatory responses and infections. The SCEMN patch has excellent antioxidant and antibacterial properties and can effectively improve the healing of diabetic wounds.

Macrophage phenotype conversion

Nanofibers prepared by electrospinning technology can guide macrophages to convert from M1 to M2 and promote wound healing. The SCEMN patch also showed the ability to promote macrophage polarization from M1 to M2 in in vivo experiments, which is crucial for wound healing and inflammation regulation.

Development of innovative materials

Electrospinning technology continues to promote the development of new biomaterials that show excellent performance in biocompatibility, biodegradability and functionality. As a new type of fiber-reinforced hydrogel microneedle patch, the SCEMN patch represents an innovative attempt in the field of microneedle technology, which has shown significant effects in tissue adhesion and wound healing.

Conclusion

In summary, electrospinning technology and SCEMN patch are closely related in terms of preparation process, biomedical application, promotion of wound healing, antioxidant and antibacterial properties, and macrophage phenotype conversion. These technologies are promoting the development of biomaterials science and providing new ideas and methods for the treatment of infected wounds.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1007/s42765-024-00439-z