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Novel TAN-delivered silk scaffolds were prepared by mixing silk fibroin solution with different concentrations of Tanshinone IIA (TAN) solution. These scaffolds exhibited a porous network structure that facilitated cell adhesion, migration, and the transport of nutrients and metabolic waste.
TAN-delivered silk scaffolds were non-toxic to chondrocyte proliferation, and enhanced chondrocyte activity, inhibited apoptosis, and reduced oxidative stress-induced damage in vitro.
In the nude mouse model, the cavitary structure of the TAN10-delivered silk scaffold group was significantly more mature and abundant than that of the silk scaffold group, indicating that the TAN10-delivered silk scaffold enhanced the formation and maturation of cartilage tissue in vivo.
In the rabbit cartilage defect model, the cartilage defect in the TAN10-delivered silk scaffold group was completely repaired, and the surface of the regenerated tissue was smooth and white, similar to the surrounding tissue, indicating that the TAN-delivered silk scaffold helped to improve the biomechanical properties and enhance the production of ECM, thereby promoting the function of new cartilage.
Electrospinning technology can be used to prepare silk fibroin/chitosan composite materials, which have excellent mechanical properties, plasticity, adjustable porosity and pore size, and complementary advantages in components in tissue engineering. This shows that electrospinning technology can be used to improve the performance of silk fibroin scaffolds, especially in improving their mechanical properties and regulating their degradation rate.
As a natural protein biomaterial, silk fibroin has excellent biocompatibility and biodegradability and is an important material in tissue engineering. Silk fibroin nanofibers prepared by electrospinning technology can be used to construct tissue engineering scaffolds to provide a better cell growth environment.
Ideal cartilage tissue engineering scaffolds should have good elasticity, material exchange capacity and biocompatibility. Electrospinning technology can prepare silk fibroin scaffolds with these characteristics to meet the needs of cartilage tissue engineering.
In summary, silk fibroin scaffolds show great potential in cartilage tissue engineering, especially when combined with tanshinone IIA (TAN), its ability to promote cartilage regeneration has been significantly enhanced. The application of electrospinning technology provides a new method for improving the performance of silk fibroin scaffolds, which helps to develop scaffold materials that are more suitable for cartilage tissue engineering.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1021/acsami.0c03822
