Electrospinning Device: Stabilization and sustained release of fragrance using Silk-PEG microspheres

Background

Silk fibroin has broad application prospects in the field of drug delivery due to its excellent biocompatibility and biodegradability. Silk fibroin microspheres can be prepared by self-assembly, and electrospinning technology can seal these drug-loaded microspheres into electrospun nanofibers to form a silk fibroin microsphere/electrospun nanofiber composite carrier.

Principle and application of electrospinning technology

Electrospinning technology can spin polymer solutions under high voltage static electricity to prepare fibers with diameters ranging from tens to hundreds of nanometers. These fibers have high porosity and large specific surface area, diverse components, and high application value in biomedicine and other fields.

Application of electrospinning technology in cartilage tissue engineering scaffolds

Electrospinning technology uses the electric field force provided by high-voltage power supply to directly and continuously prepare nanofibers, which is conducive to the compounding of bioactive factors and can also avoid polymer degradation and scaffold structure damage caused by high temperature.

Stabilization of silk fibroin microspheres and sustained release of fragrances

Wang Xiaoqin's team explored the ability of Silk-PEG microspheres to stabilize and continuously release fragrances. Volatile fragrances are encapsulated in the silk fibroin microspheres formed in the solution through a quick and easy operation to minimize the loss of fragrance.

Advantages of preparing silk fibroin microspheres by electrospinning technology

The fiber scaffolds prepared by electrospinning technology can better mimic the natural ECM in terms of microscopic size and distribution structure, which is conducive to cell adhesion and tissue regeneration.

Combination of silk fibroin microspheres and electrospinning

Through electrospinning technology, silk fibroin microspheres can be coated in nanofibers to form a composite carrier with a "core-shell" structure. This structure helps to solve the problem of "burst release" in the early stage of drug release and provide a new carrier form.

The importance of electrospinning technology in tissue engineering

The nanofiber scaffolds prepared by electrospinning technology are widely used in regenerative medicine because of their advantages such as being able to simulate the natural structure of the extracellular matrix, especially in the fields of nerve, myocardium, tendon, bone tissue regeneration and wound healing, showing great application potential.

Summary

In summary, electrospinning technology plays an important role in the preparation and application of silk fibroin microspheres. It can not only increase the loading capacity and stability of spices, but also control the release rate by forming a composite carrier, providing a new method and carrier form for the application of silk fibroin in the field of drug delivery and tissue engineering.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acsbiomaterials.3c00064