Electrospinning Device: Study on water-responsive self-shrinkable silk-based skin anti-aging tensiometer with customizable biological functions

Background

Electrospinning technology is widely used in skin anti-aging treatment because it can prepare nanofibers with high specific surface area and high porosity. These nanofibers can mimic the structure of the extracellular matrix (ECM), provide the necessary support and guidance for cells, and promote cell proliferation and the growth of new tissues. As a natural material, silk fibroin can be prepared into nanofibers with specific functions through electrospinning technology for skin tension regulation and anti-aging treatment.

Development of self-shrinking silk skin tension agents (SSSTs)

Inspired by the natural supercontraction of spider silk, researchers developed self-shrinking silk skin tension agents (SSSTs) by adjusting the molecular structure of silk fibroin fibers. This material has water-responsive self-shrinkage ability and can be used to regulate skin tension, improve and delay skin aging. Electrospinning technology can be used to prepare nanofibers with similar functions to enhance skin tension and improve skin aging.

Drug loading and sustained release ability

Electrospinning technology can prepare drug-loaded nanofibers to achieve ideal encapsulation and loading of drugs, and play a good therapeutic role by adjusting the release of drugs from the scaffold. SSSTs are also designed to have drug loading and sustained release capabilities. By loading ampicillin sodium on SSSTs, slow drug release and antibacterial functions are achieved, reducing postoperative inflammatory reactions.

Near-infrared laser heating function

Electrospinning technology can prepare nanofibers with near-infrared light heating function, which is designed and realized using the photothermal conversion performance of gold nanorod materials. The near-infrared light heating function of SSSTs effectively increases the subcutaneous temperature, showing its potential to enhance and prolong the skin lifting effect.

Biocompatibility and biodegradability

Nanofibers prepared by electrospinning technology have good biocompatibility and biodegradability, which are essential for implanting biomaterials. SSSTs also show good biocompatibility, indicating their applicability in vivo.

Tissue engineering and skin tension regulation

Electrospinning technology is widely used in tissue engineering to prepare bioscaffold materials to provide necessary support and guidance for cells. As a new type of skin tension regulation smart material, SSSTs provide a new and effective treatment method for enhancing skin tension and improving or delaying skin aging.

Summary

In summary, there is a close connection between electrospinning technology and the application of silk fibroin in skin anti-aging treatment. Electrospinning technology can prepare silk fibroin-based nanofibers with specific functions. These nanofibers show great potential in skin tension regulation, drug sustained release, antibacterial and near-infrared light heating, providing new ideas and methods for skin anti-aging treatment.

Electrospinning Nanofibers Article Source:

http://doi.org/10.1002/adhm.202400671