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Significant synergistic antibacterial effect: The system has broad-spectrum antibacterial properties against common pathogens such as Staphylococcus aureus and Escherichia coli through SF microspheres to induce bacterial adhesion and silver antibacterial effect. The combination of SFM-AgNPs and antibiotics expands the antibacterial spectrum, reduces the dosage of antibiotics and improves the efficacy.
Effectively destroy the biofilm structure: In in vitro experiments, after treatment with HA@Mup@SFM-AgNPs MNs, the biofilm structure almost disappeared, and the bacteria ruptured and dissolved. It can penetrate into the biofilm, destroy the cell membrane and cell wall of the bacteria, and cause bacterial death.
Promote wound healing: In vivo experiments show that the microneedle system can not only effectively eliminate biofilms, but also reduce inflammation, promote tissue regeneration, and accelerate the healing of infected wounds. There is less inflammatory cell infiltration at the beginning of treatment, and the inflammatory period is shortened at the end of treatment, and the healing is good.
Preparation of nanofiber structure: Electrospinning equipment can prepare silk protein nanofibers with specific structures and properties. These nanofibers can be used to construct finer microneedle structures and further optimize their performance. For example, silk protein nanofibers prepared by electrospinning technology can be compounded with silver nanoparticles and antibiotics to form composite microneedles with better mechanical properties and antibacterial properties.
Regulating the microstructure of microneedles: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of the microneedle to be precisely regulated, thereby better meeting the needs of bacterial biofilm infection treatment and providing a suitable microenvironment for the release of antibacterial drugs and bacterial adhesion.
Loading bioactive substances: Electrospinning equipment can prepare nanofiber microneedles loaded with bioactive molecules. For example, growth factors and drugs that promote wound healing are loaded into silk fibroin nanofibers and then combined with microneedles. By controlling the release rate, the sustained action of bioactive substances at the infection site can be achieved. This can not only enhance the biological function of microneedles, but also further improve their effect in the treatment of bacterial biofilm infections.
In summary, HA@Mup@SFM-AgNPs MNs show good application effects in the treatment of bacterial biofilm infections, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, nanofiber microneedles with specific structures and properties can be prepared, and the performance of HA@Mup@SFM-AgNPs MNs can be further optimized to improve its application effect in the treatment of bacterial biofilm infections.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1016/j.jcis.2024.01.147
