Copyright © 2022 Foshan MBRT Nanofiberlabs Technology Co., Ltd All rights reserved.Site Map
Electrospinning technology and biology
Nanofibers prepared by electrospinning Electrospinning technology has been widely used in biological medicine field.Benefit from the rapid development of nanotechnology, also benefit from its unique material properties.The nanofibers prepared by electrospinning have strong plasticity, flexible structure, large specific surface area, high porosity, can simulate the extracellular matrix to the greatest extent, which can enhance the adhesion, proliferation and differentiation of cells.Electrospinning allows nanosurface modification of tissue-engineered materials, controlling protein adsorption and biological medicine construction of protein layers to build ‘bottom-up’ nanoscale features. Can be used to direct surface hydrophilicity, oxide thickness or functional group distribution, form extracellular matrix-like nanostructures, mimic biological environments and influence cell behaviour, signal transduction and nutrient transport, etc. |
|
| Electrospinning nanofiber materials are becoming more and more suitable for building drug delivery systems. Not only because of its good biocompatibility and safety, but also because of its large specific surface-volume ratio, allows the drug to maintain a high efficacy at a lower cost. More notably, electrostatic spinning nanofibers also provide flexibility in the selection of drug loading materials and a variety of drug loading methods, such as coating and encapsulation.
|
Case——Application in the field of skin tissue repair
| Nanofiber dressing Skin burns, wounds, diabetes and other causes will lead to skin defects or loss of function, affecting people's life and health, so it is necessary to develop wound dressings with excellent performance, shorten the time of wound repair and promote wound repair. Electrospinning technology is widely used in the preparation of wound repair materials, because of its simple operation, low cost and no change in the characteristics of the solution itself. At the same time, natural biomaterials because of their wide range of sources and non-immunogenicity, can play a unique role in the trauma repair process. Therefore, nanofiber dressing prepared by electrospinning natural biological materials has a broad development prospect in the skin wound repair field. |
Waterproof and breathable | Non-immunogenicity | Bacteriostasis and hemostasis | Simulating extracellular matrix |
Electrospinning fiber membranes have high porosity, supports gas exchange and good breathability, providing a moist environment for wounds and facilitating cell respiration. | Natural biological materials have a wide range of sources, are non-immunogenic, can exert its unique advantages in the process of wound repair. | Electrospinning fiber membranes can isolate most of the bacteria and dust in the air, thereby achieving antibacterial effects, has a high specific surface area, small pore size, and certain hemostatic functions. | Electrospinning nanofiber membrane can simulate the structure and function of extracellular matrix, promote the synthesis of multiple factors, facilitate cell adhesion, proliferation and differentiation, promote wound healing. |
Case——Application in the field of tissue engineering scaffold
Electrospinning technology can produce high quality and highly customized support materials. The fibers in these materials can perfectly replicate the microstructure of human tissue and have good compatibility. In bone tissue, these scaffold can provide a microenvironment similar to bone structure, providing support for bone cell adhesion, proliferation, and differentiation. It has a high surface area and porous structure, help the growth of cells and the formation of new bone tissues, promote the healing of fractures and repair of bone defects. Nanofiber scaffolds provide a surface similar to bone matrix that promotes the attachment and proliferation of bone cells. The use of scaffolds can provide support for the adhesion and growth of endothelial cells, successfully induce new angiogenesis. In addition, it has been reported that electrospinning technology has also been applied in tissues such as nerves and tendons, these applications are expected to promote the development of tissue repair and regeneration, providing new solutions for the functional recovery of human tissues and disease treatment. |
|
Bone repair materials | Cartilage repair scaffold | Intravascular stent | Nerve and tendon |
Electrospinning fiber scaffold has the advantages of similar structure to natural bone, good biocompatibility, promoting tissue growth and suitable degradation time. | These scaffolds are elastic in the wet state, the nanofiber membranes have good bioactivity and osteogenic ability, provides a promising material for the overall repair of bone and cartilage. | The nanofiber composite scaffold prepared by electrospinning has good biocompatibility, support smooth muscle cells and vascular endothelial cells to proliferate on it, and has been widely used in the treatment of vascular diseases. | Electrospinning can be combined with other traditional biotechnologies (such as hydrogel "perfusion" systems, template forming, freeze drying, etc.) to construct scaffolds for nerve and tendon repair. |
Case——Applications in the field of drug delivery
Traditional drug delivery methods are oral, injection, inhalation, etc. These methods sometimes have some shortcomings, such as difficult to control the dose, rapid drug metabolism, local delivery difficulty. In addition, drug delivery also faces some special needs, such as controlling drug release speed and treating local wounds. Using model drugs and polymer solutions prepared by electrostatic spinning drug-carrying nanofiber membrane, for some clinical difficulties in mastering drug delivery time and poor patient compliance of drugs, such as anti-hypertensive drugs, hypoglycemic drugs and hypolipidemic drugs, etc., can be made into electrostatic spinning drug delivery system, it can be fully based on the pathophysiological characteristics of the disease release of the drug, achieve the same pathophysiological characteristics with the disease or the timing of the disease. Intelligent drug delivery effect, improve its bioavailability and reduce adverse drug reactions, reduce adverse drug reactions, Electrospinning technology can carry proteins, peptides, DNA, proteases, growth factors and other biological macromolecules through coating, embedding to control the release and increase biocompatibility. Currently, the application of electrospinning in drug delivery mainly includes anti-inflammatory, anti-oxidation, anti-tumor, etc. |
|
Anti-inflammatory | Antioxidant | Antineoplastic |
Chronic inflammation in tissue regeneration has side effects, greatly inhibits tissue repair or regeneration.Traditional anti-inflammatory drugs are released locally through physical encapsulation into the carrier, faced with the challenge of uncontrolled. There is an urgent need to construct a prodrug that can modulate chronic inflammation by releasing anti-inflammatory drugs. | Preventing bacterial contamination, maintaining REDOX balance in the environment, accelerating wound healing are the key requirements of wound dressings. The novel composite nanofibers have broad application prospects in skin care, tissue regeneration and wound healing. | Many anticancer drugs are cytotoxic to normal cells at high concentrations, while at the same time, if the effective concentration is not reached, the anticancer effect is not satisfactory. The nanofiber method can strike a balance between cytotoxicity and effective concentration. Sustained release not only prolongs the duration of effective concentration but also reduces the time to peak levels. |
Foshan MBRT Nanofiberlabs Technology Co., Ltd. has a complete electrospinning nanofiber solution. Nanofibers help biomedical innovation and make biological research more effective.
Product link: https://www.nanofiberlabs.com/products-category/lab-scale.html
