Research background:
Electrospinning is a simple and universal method for preparing nanofiber dressings. Compared with traditional dressings such as cotton gauze and medical sponge, electrospun nanofiber dressings promote the adhesion, migration and proliferation of skin fibroblasts and accelerate wound healing. In addition, electrostatic spinning nanofibers have good microbial barrier properties and good moisture permeability. They can also serve as a good carrier for loading various bioactive agents and/or even living cells, further giving electrostatic spinning dressings the intended biological function or even multiple functions, significantly improving the healing effect of different chronic skin wounds, while greatly shortening the treatment time procedure.

Recently, the team of Professor Shaojuan Chen of Qingdao University published a review on the challenges of treating diabetic wounds and the potential of electrospun nanofibers to promote wound healing. The relevant research results are entitled "Recent Advances in Electrospun Nanofiber-Based Strategies for Diabetic Wound Healing Application". Published in the journal 《Pharmaceutics》.

Key points of this article:
1. This paper first briefly introduces diabetic ulcer and electrospinning process, and then introduces the latest development of diabetic wound treatment strategy based on electrospinning in detail.
2. The synergistic application of electrospinning with bioactive ingredients and/or cell therapy is highlighted.
3. The advantages of hydrogel dressing prepared by electrostatic spinning nanofibers were discussed.
4. The challenges and prospects of treatment strategies for diabetic wounds based on electrospinning were discussed in depth.

How can electrospun nanofibers promote wound healing in diabetic ulcers?

1. The small fiber diameter and large specific surface area of electrospun nanofibers simulate the extracellular matrix (ECM) of natural tissues, which can promote cell adhesion, migration and proliferation.

2. Electrospun nanofibers can carry bioactive substances, such as antibiotics, metal nanoparticles, and antimicrobial peptides, which can improve the healing process by controlling inflammation, preventing infection, and promoting tissue regeneration.

3. Electrospun nanofibers have high porosity and small pore size, as a natural barrier to effectively prevent the infection of external pathogenic microorganisms, while ensuring the permeability of the wound.

4. Electrospun nanofibers have a variety of functions, such as hemostasis, antibacterial, antioxidant, regulating inflammation and promoting angiogenesis, etc. These functions are very important for the treatment of diabetic wounds that are difficult to heal.

What are the potential applications of electrospun nanofibers in wound healing?

Potential applications of electrospun nanofibers in wound healing include personalized therapy, design of smart nanofibers as well as clinical applications.

1. Personalized therapy: involves customizing the properties of electrospun nanofibers to meet the specific needs of individual patients, thereby improving treatment outcomes.

2. Design of smart nanofibers: refers to the development of advanced nanofibers with intelligent functions, such as controlling drug release or responsive behavior to specific wound conditions, thereby improving the effectiveness of wound healing.

3. Clinical application: Electrospun nanofibers have been used in clinical Settings as a standard treatment modality for various types of wounds, including diabetic wounds. These future applications indicate the great potential of electrospun nanofibers in the field of wound healing.

Figure 1: Various application strategies for diabetic ulcer management based on electrospinning.

Figure 2 (A) Schematic diagram of a conventional electrospinning device. (B) Blended electrospinning. (C) emulsion electrospinning. (D) side-by-side electrospinning. (E) coaxial electrospinning.

Figure 3: (A) Schematic diagram of an improved electrospinning system for the production of PLLA NYs. (B) Mechanical properties of PLLA. (C) Wound healing at 1, 2 and 3 weeks after transplantation. (D) CCK-8 cell viability assay results. (E) Quantitative data on hemolysis rate.

Figure 4: Electrospun nanofiber dressings loaded with bioactive agents

Figure 5: Development and application of electrospinning nanofiber/hydrogel composite dressing for DUs treatment.

Figure 6: Development and application of electrospinning double-layer nanofiber/hydrogel composite dressing for DUs treatment.

 Original text link：https://doi.org/10.3390/pharmaceutics15092285

 Related link: 

https://www.nanofiberlabs.com/product/multifunctional-electrospinning-machine-e04-001.html