Electrospining Machine: Electrospun Nanofbers for Accelerated Wound Healing

Background

Electrospun Nanofbers have promising applications in wound healing. The introduction of inorganic components (e.g., metal oxides, carbon nanotubes, and graphene) endows HNFs with excellent antimicrobial, antioxidant, and pro-angiogenic properties. By modulating the type, content and morphology of inorganic components, the properties of HNFs can be tailored to meet specific wound healing needs. In addition, the application of drug loading strategies further enhances the therapeutic effects of HNFs.

The main points of this paper

1.This paper reviews the recent progress of Electrospun Nanofbers in wound healing.

2.It focuses on the types of inorganic components, doping methods and effects on the wound healing process.

3.Finally, the challenges and future directions of Electrospun Nanofbers in wound healing are discussed.

What are the advantages of Electrospun Nanofbers for wound healing?

1. Mimics the skin's natural extracellular matrix (ECM), making it a promising candidate for wound therapy.

2. Have high porosity, large specific surface area and appropriate mechanical strength.

3. Be able to control the delivery and release of biomolecules and drugs, expanding their applications in wound healing.

4. Enhances the bioactivity of Nanofiber Membrane by combining inorganic components with organic matrix.

5.Accelerates wound healing by promoting hemostasis, antimicrobial properties, anti-inflammatory effects, promoting cell proliferation and facilitating angiogenesis.

What are the different fabrication methods for Electrospun Nanofbers?

1.Industrial Electrospinning machine production Line: 

Organic matrix and inorganic nanoparticles are mixed and then directly electrospun. This is the simplest and most efficient method, but due to the high viscosity of the polymer solution, the distribution of the various components may not be uniform.

2.Needle-Based Industrial Electrospinning machine:

This method involves the use of multi-channel needles to construct core-shell nanofibers, where the core solution usually contains inorganic nanoparticles dissolved in a solvent or polymer solution, while the shell solution is another polymer solution.

3.Scale-up Electrospinning machine:

The electrospun nanofiber membrane is immersed in inorganic material and nanoparticles are formed on the fiber surface. This method ensures that the inorganic nanomaterials are uniformly distributed on the surface of the Electrospun nanofibers.

Originallink: https://doi.org/10.1039/D4TB00149D