Electrospinner: Add some calcium and acid to achieve green and efficient spinning

Mechanism of action of Ca2+

The mechanism of action of Ca2+ in SF LLPS includes charge shielding to increase hydrophobic interactions and salt bridge formation through electrostatic interactions. This finding is crucial for understanding the spinning mechanism of silk protein.

LLPS and spinning process

LLPS is a key step in the silk spinning process, which involves the transformation of SF from solution to coacervate. The application of acidification and shear force further promotes the transformation of coacervate to fibril, simulating the environmental factors in the natural silk spinning process.

Bionic spinning method

The biomimetic spinning method developed by the researchers is not only environmentally friendly and energy efficient, but also helps to understand the spinning mechanism of silk. This method may be of great significance for industrial-scale silk protein production.

Application of electrospinning technology

Electrospinning technology shows great potential in the preparation of SF-based fiber scaffolds, especially in the field of tissue engineering. SF/PLGA fiber scaffolds with good cell compatibility and mechanical properties can be prepared by electrospinning technology.

Environmental and economic impact

Traditional spinning methods rely on high-concentration SF solutions and organic solvents, while the new method reduces environmental pollution and energy consumption, and has better environmental and economic benefits.

Future research directions

Future research can further explore the specific mechanism of action of Ca2+ and other ions in SF LLPS, and how to optimize spinning conditions to improve fiber quality and yield. In addition, researchers can explore the application potential of this biomimetic spinning method in other protein-based materials.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1038/s41467-024-54588-1