Electrospinning Device: Biomimetic natural silk nanofiber microspheres for multifunctional biomedical applications

Background

Electrospinning is a mature high-voltage electric field-assisted nanofiber material manufacturing technology that has been proven to have the potential to promote periodontal tissue regeneration and has been widely used in the field of tissue engineering. SNFs, as a high-potential protein nanofiber material, have not been fully developed in biomedical applications. SNFs were stripped from silk by all-water treatment and used as the cornerstone for the construction of microspheres. These natural silk nanofiber-based microspheres showed potential for application in tissue engineering, early disease diagnosis, and therapeutic devices.

Extracellular matrix (ECM) mimetic structure

Inspired by the structure and bioactive components of ECM, hyaluronic acid (HA) was used as a bioglue to regulate the assembly of SNFs. With the help of HA, SNF microspheres with a stable and fluffy nanofiber structure were synthesized by electrospraying, which mimicked the properties of ECM, endowing the microspheres with excellent biocompatibility and enhanced osteogenic differentiation induction ability of mesenchymal stem cells.

Multifunctionality and Modification

SNF microspheres can be further functionalized with other molecules and nanomaterials, and their excellent blood compatibility and modifiability from the molecular level to the nanoscale have been used to demonstrate their wide applications in protease detection and blood purification. This is similar to the unique advantages of nanofiber membranes prepared by electrospinning technology in periodontal treatment. Electrospun nanofibers can improve protein absorption capacity, promote the expression of specific genes, and improve cell adhesion properties.

Biocompatibility and Biodegradability

SNF microspheres have good biocompatibility and biodegradability based on biogenic chemical composition and biomimetic nanofiber structure, which makes them suitable for long-term scaffolds in vivo for SCI treatment. Materials prepared by electrospinning technology are also widely used in the biomedical field due to their excellent biocompatibility and biodegradability.

Tissue Engineering and Regenerative Medicine

The ability of SNF microspheres in promoting osteogenic differentiation of bone marrow mesenchymal stem cells makes them potentially useful in tissue engineering and regenerative medicine. Electrospinning technology also plays an important role in the field of tissue engineering, promoting cell growth and tissue regeneration by preparing nanofiber scaffolds with specific structures and functions.

Conclusion

In summary, the connection between electrospinning technology and SNFs in biomedical applications is reflected in their common biocompatibility, biodegradability, multifunctionality and potential applications in tissue engineering and regenerative medicine. These characteristics make them an important tool for the development of new biomedical materials and therapeutic strategies.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acsnano.2c06331