Electrospinning Device: Biomimetic scaffold designed by combining silk protein nanofibers and hyaluronic acid

Background

Electrospinning is a key technology for preparing high-performance, multifunctional nanofibers that meet the needs. SNFs, as a high-potential protein nanofiber material, can be assembled into nanofiber aerogel scaffolds with ideal shapes and low density on a large scale through electrospinning technology, providing a promising strategy for tissue regeneration.

Simulating extracellular matrix (ECM)

Electrospinning technology can prepare nanofiber scaffolds that simulate the structure and function of ECM. The biomimetic nanofiber scaffold formed by the combination of SNFs and hyaluronic acid (HA) not only mimics the composition of ECM, but also mimics the hierarchical structure of ECM, providing a favorable microenvironment for cell adhesion and proliferation.

Improving biocompatibility and cell infiltration

Nanofibers prepared by electrospinning technology have attracted continuous attention from researchers in the biomedical field due to their high specific surface area and porous structure, and have been well applied in drug controlled release, wound repair, and biological tissue engineering. SNFs scaffolds show excellent biocompatibility and cell infiltration, providing a good growth environment for cells.

Enhanced mechanical properties

Electrospinning technology can obtain nanofibers with different structural characteristics by changing the nozzle structure and controlling the experimental conditions, thereby regulating the mechanical properties of the scaffold. The presence of HA significantly improves the hydrophilicity and bioactivity of silk nanofibers, enhances the interaction between SNFs, and significantly improves the mechanical properties of the composite scaffold.

Multifunctionality and application expansion

Nanofibers prepared by electrospinning technology show extraordinary versatility, opening up countless possibilities in the fields of materials science and biomedicine. The versatility of SNFs scaffolds enables them to show excellent performance in protease detection and blood purification, expanding their potential in biomedical applications.

Summary

In summary, the combination of electrospinning technology and SNFs provides a new type of bionic nanofiber scaffold for tissue engineering. This scaffold successfully simulates ECM in structure and function, has good biocompatibility, mechanical properties and structural stability, and provides a new strategy and material selection for tissue engineering and regenerative medicine.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.ijbiomac.2023.128762