Electrospinning Device: Design of silk fibroin microspheres for the development of biosafe sunscreens

Background

Silk fibroin microspheres (SFMPs) are widely used in cosmetics due to their unique functions, including biocompatibility, moisturizing, nourishing, and whitening. SFMPs have inherent UV absorption capacity, which is attributed to the presence of aromatic amino acid residues, such as tryptophan, tyrosine, and phenylalanine. Electrospinning technology can be used to prepare nanofibers with similar UV absorption capacity, which can be used to develop efficient sunscreen products.

Photostability of nanofibers

SFMPs showed good photostability and slow degradation within 8 h, which is sufficient for daily use. This stability may be attributed to the β-sheet conformation of SFMPs. Nanofibers prepared by electrospinning technology can also have excellent photostability, which is an important property for sunscreen materials.

Antioxidant capacity

SFMPs ​​have stronger antioxidant capacity than titanium dioxide and SF, which may be because amino acids containing phenolic hydroxyl groups, such as tyrosine, are transferred to the molecular surface during the self-assembly process. Electrospinning technology can be used to prepare nanofibers with antioxidant capacity, which can be used to protect the skin from free radical damage.

Cytotoxicity and UV shielding ability

In vitro experiments have shown that SFMPs have significant UV shielding ability and can effectively inhibit UV radiation without toxicity. Electrospinning technology can prepare nanofibers with similar properties for the development of biosafe sunscreen products.

Skin protection

In vivo experiments have shown that SFMPs are more effective than commercial sunscreens and titanium dioxide in inhibiting epidermal hypertrophy, flaking and thickening, and can reduce the secretion of inflammatory factors. Electrospinning technology can be used to prepare nanofibers with these properties to enhance the protective effect of the skin.

Application prospects of electrospinning technology

Electrospinning technology is widely used in tissue engineering, medical engineering, electrochemical engineering and other fields due to its simplicity, cost-effectiveness and good controllability. Combined with the research on SFMPs, electrospinning technology is expected to play an important role in the development of new biosafe sunscreens, and provide new solutions for sunscreen products by preparing nanofibers with excellent UV protection, antioxidant and anti-inflammatory properties.

In summary, there is a close connection between electrospinning technology and the potential of SFMPs in developing biosafe sunscreens, and the combination of the two provides new possibilities for the innovative development of sunscreen products.

Electrospinning Nanofibers Article Source:

http://doi.org/10.1021/acsami.3cl7879