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The study published by Jeong-Yong Lee's team in the journal Frontiers In Nutrition explored the anti-aging effects of dietary silk peptides (SP) on mice of different ages. The study pointed out that immunosenescent cells may play a harmful role in the immune system, so the effects of SP on 14-month-old C57BL/6 mice were studied to determine its regulatory effects on immune homeostasis.
In the study, young (2 months old) and old (14 months old) C57BL/6 mice received daily oral doses of acid hydrolyzed silk peptides (SP) for 5 weeks. The spleen, lymph nodes and serum of mice were analyzed by flow cytometry, western blot, ELISA and qRT-PCR to evaluate the effects of SP on immune homeostasis.
Improvement of T cell and B cell dysfunction: The study found that SP can improve age-related T cell and B cell dysfunction, especially B cell dysfunction, thereby improving immunoglobulin responses in old mice.
Restoration of immune homeostasis: After SP treatment, the number of CD3 T cells in the spleen cell population of old mice decreased, approaching the level of young mice. SP also reduced the amount of IL-10 released by helper T cells in old mice, making it similar to the level of young mice.
Expression of T cell/B cell interaction markers: After SP treatment, the expression levels of co-stimulatory markers related to the interaction between T cells and B cells in the spleen cells of old mice decreased, and there was no significant difference from the levels of young mice.
Effects on MZ B cells and immunoglobulin levels: After SP treatment, the number of MZ B cells in old mice increased, and the increased levels of IgA, IgM, and IgG were reduced.
Effects related to cell apoptosis: SP reduced the thickness of MOMA bands in old mice and regulated the expression of genes related to cell cycle arrest and apoptosis, affecting cell apoptosis during aging.
Immunomodulatory effects: According to the search results, electrospun fibers are widely used in tissue repair because they can guide a large number of cellular responses, including phenotypic differentiation and tissue maturation. This is relevant to the research of Jeong-Yong Lee's team, as they found that dietary silk peptides (SP) were able to improve age-related T cell and B cell dysfunction, thereby improving immunoglobulin responses in aged mice. This suggests that materials prepared by electrospinning technology may have the potential to modulate immune responses, similar to the improvement of immune cell function observed by SP in the study of Jeong-Yong Lee's team.
Tissue Repair and Regeneration: Electrospinning technology plays an important role in regenerative medicine, especially in immunoengineering based on electrospun fibers. The study of Jeong-Yong Lee's team mentioned that SP restored the homeostasis of the aged immune system by regulating the number and activity of T cells and B cells, which may complement the role of electrospun fibers in tissue repair and immunomodulation.
The study concluded that SP restored the homeostasis of the aged immune system by regulating the number and activity of T cells and B cells, reduced the age-related increase in the number of T cells and cytokines, and regulated the interaction between T cells and B cells in aged mice, reduced immunoglobulin levels, and alleviated MOMA bands, thereby affecting senescent cell apoptosis.
Electrospinning Nanofibers Article Source:
https://doi.org/10.3389/fnut.2020.583186
