Electrospinning Device: Silk fibroin membrane with tapered microporous channels for in situ bone repair

Background

Zou Duohong's team published a research article in Advanced Materials titled "Harmonizing Thickness and Permeability in Bone Tissue Engineering: A Novel Silk Fibroin Membrane Inspired by Spider Silk Dynamics", proposing a new type of silk membrane (CSMP-DSF membrane), which solves the interaction between thickness and permeability of guided bone regeneration (GBR) membranes by imitating the water collection mechanism of spider silk. This double-layer membrane design combines a smooth dense layer with a rough loose layer to achieve a directional fluid transport function, which is of great significance for in situ bone repair.

Preparation and properties of CSMP-DSF membrane

This study used a two-step method to prepare the CSMP-DSF membrane. First, the dense layer was prepared by self-evaporation, and then the loose layer was prepared by freeze-drying technology. This design allows the dense layer to provide strong mechanical properties, while the loose layer promotes the attachment of osteoblast-related cells and degrades faster than the dense layer, exerting its osteogenic potential

Application of electrospinning technology in bone tissue engineering

Electrospinning technology has received widespread attention in bone tissue engineering because of its ability to produce precisely arranged nanofiber scaffolds with nanoscale structures. These nanofiber scaffolds can promote the growth of new bone tissue and enhance cell adhesion. Recent advances in electrospinning technology have provided innovative methods for scaffold manufacturing in bone tissue engineering, including multi-layer nanofibers, multi-fluid electrospinning, and the integration of electrospinning with other methods.

Potential connection between CSMP-DSF membrane and electrospinning technology

Although the study of CSMP-DSF membrane did not directly mention electrospinning technology, considering the application of electrospinning technology in the preparation of nanofibers with specific microstructures and surface properties, it can be foreseen that the two technologies may be combined in the future. For example, electrospinning technology can be used to prepare nanofibers with specific surface energy gradients and Laplace pressures, which can further enhance the liquid directional transport function of CSMP-DSF membranes and improve their efficiency and effectiveness in bone tissue engineering.

Conclusion

The research of Zou Duohong's team provides a new type of silk membrane, which solves the balance problem between thickness and permeability of GBR membrane by imitating the water collection mechanism of spider silk in nature. The development of electrospinning technology provides a new scaffold manufacturing method for bone tissue engineering. The possible combined application of these two technologies in the future will further promote the development of bone tissue engineering.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.bioactmat.2023.05.002